This chapter consists of several sections which contain contributions from members of IFIP Technical Committee 8 (Information Systems). We highlight the accomplishments of Technical Committee 8 (TC8) and its working groups over its 50 years history, and then envisage possible strategies for the future of information systems (IS) in a post-COVID world. This chapter begins with an overall view of the diverse and changing roles of the IS field then moves forward to foresee environmental sustainability and digital glocalization in a post-COVID-19 world. Next, we review the achievements of TC8, the establishment of the working groups within it, and predict what TC8 has to offer into the future. Lastly, we identify the individual working groups of TC8 to detail their activities as important conduits of research and practice in the field of IS over the past 50 years, then imagine the roles of the TC8 working groups in a post-COVID landscape.