The lower limit of quantification in pharmacokinetic analyses

Andrew Woodward, Ted Whittem

Research output: Contribution to journalComment/debatepeer-review

5 Citations (Scopus)

Abstract

Pharmacokinetic (PK) analyses rely fundamentally on independent measurements of drug concentrations in biological matrices, traditionally using chromatographic analytical methods. These methods have imperfect performance and introduce measurement error to the experiment. Commonly, the measurement error is used to constrain the report of analytical outputs. An important issue in PK is the influence of these analytical constraints on available inferences.
Original languageEnglish
Pages (from-to)585-587
Number of pages3
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume42
Issue number6
DOIs
Publication statusPublished - 1 Nov 2019
Externally publishedYes

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