The lower limit of quantification in pharmacokinetic analyses

Andrew Woodward; Ted Whittem

doi:10.1111/jvp.12778

The lower limit of quantification in pharmacokinetic analyses

Andrew Woodward, Ted Whittem

Research output: Contribution to journal › Comment/debate › peer-review

11 Citations (Scopus)

Abstract

Pharmacokinetic (PK) analyses rely fundamentally on independent measurements of drug concentrations in biological matrices, traditionally using chromatographic analytical methods. These methods have imperfect performance and introduce measurement error to the experiment. Commonly, the measurement error is used to constrain the report of analytical outputs. An important issue in PK is the influence of these analytical constraints on available inferences.

Original language	English
Pages (from-to)	585-587
Number of pages	3
Journal	Journal of Veterinary Pharmacology and Therapeutics
Volume	42
Issue number	6
DOIs	https://doi.org/10.1111/jvp.12778
Publication status	Published - 1 Nov 2019
Externally published	Yes

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10.1111/jvp.12778

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abstract = "Pharmacokinetic (PK) analyses rely fundamentally on independent measurements of drug concentrations in biological matrices, traditionally using chromatographic analytical methods. These methods have imperfect performance and introduce measurement error to the experiment. Commonly, the measurement error is used to constrain the report of analytical outputs. An important issue in PK is the influence of these analytical constraints on available inferences.",

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AB - Pharmacokinetic (PK) analyses rely fundamentally on independent measurements of drug concentrations in biological matrices, traditionally using chromatographic analytical methods. These methods have imperfect performance and introduce measurement error to the experiment. Commonly, the measurement error is used to constrain the report of analytical outputs. An important issue in PK is the influence of these analytical constraints on available inferences.

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M3 - Comment/debate

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JO - Journal of Veterinary Pharmacology and Therapeutics

JF - Journal of Veterinary Pharmacology and Therapeutics

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The lower limit of quantification in pharmacokinetic analyses

Abstract

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