Abstract
In order to maintain their unlimited capacity to divide, stem cells require controlled temporal and spatial protein expression. The Musashi family of RNA-binding proteins have been shown to exhibit this necessary translational control through both repression and activation in order to regulate multiple stem cell populations. This chapter looks in depth at the initial discovery and characterisation of Musashi in the model organism Drosophila, and its subsequent emergence as a master regulator in a number of stem cell populations. Furthermore the unique roles for mammalian Musashi-1 and Musashi-2 in different stem cell types are correlated with the perceived diagnostic power of Musashi expression in specific stem cell derived oncologies. In particular the potential role for Musashi in the identification and treatment of human cancer is considered, with a focus on the role of Musashi-2 in leukaemia. Finally, the manipulation of Musashi expression is proposed as a potential avenue towards the targeted treatment of specific aggressive stem cell cancers.
| Original language | English |
|---|---|
| Title of host publication | Transcriptional and Translational Regulation of Stem Cells |
| Editors | Gary Hime, Helen Abud |
| Place of Publication | Dordrecht, Netherlands |
| Publisher | Springer |
| Chapter | 13 |
| Pages | 233-245 |
| Number of pages | 13 |
| Volume | 786 |
| ISBN (Electronic) | 9789400766211 |
| ISBN (Print) | 9789400766204 |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 786 |
| ISSN (Print) | 0065-2598 |
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The Musashi family of RNA binding proteins : Master regulators of multiple stem cell populations. / Sutherland, Jessie M.; McLaughlin, Eileen A.; Hime, Gary R.; Siddall, Nicole A.
Transcriptional and Translational Regulation of Stem Cells. ed. / Gary Hime; Helen Abud. Vol. 786 Dordrecht, Netherlands : Springer, 2013. p. 233-245 (Advances in Experimental Medicine and Biology; Vol. 786).Research output: A Conference proceeding or a Chapter in Book › Chapter
TY - CHAP
T1 - The Musashi family of RNA binding proteins
T2 - Master regulators of multiple stem cell populations
AU - Sutherland, Jessie M.
AU - McLaughlin, Eileen A.
AU - Hime, Gary R.
AU - Siddall, Nicole A.
PY - 2013
Y1 - 2013
N2 - In order to maintain their unlimited capacity to divide, stem cells require controlled temporal and spatial protein expression. The Musashi family of RNA-binding proteins have been shown to exhibit this necessary translational control through both repression and activation in order to regulate multiple stem cell populations. This chapter looks in depth at the initial discovery and characterisation of Musashi in the model organism Drosophila, and its subsequent emergence as a master regulator in a number of stem cell populations. Furthermore the unique roles for mammalian Musashi-1 and Musashi-2 in different stem cell types are correlated with the perceived diagnostic power of Musashi expression in specific stem cell derived oncologies. In particular the potential role for Musashi in the identification and treatment of human cancer is considered, with a focus on the role of Musashi-2 in leukaemia. Finally, the manipulation of Musashi expression is proposed as a potential avenue towards the targeted treatment of specific aggressive stem cell cancers.
AB - In order to maintain their unlimited capacity to divide, stem cells require controlled temporal and spatial protein expression. The Musashi family of RNA-binding proteins have been shown to exhibit this necessary translational control through both repression and activation in order to regulate multiple stem cell populations. This chapter looks in depth at the initial discovery and characterisation of Musashi in the model organism Drosophila, and its subsequent emergence as a master regulator in a number of stem cell populations. Furthermore the unique roles for mammalian Musashi-1 and Musashi-2 in different stem cell types are correlated with the perceived diagnostic power of Musashi expression in specific stem cell derived oncologies. In particular the potential role for Musashi in the identification and treatment of human cancer is considered, with a focus on the role of Musashi-2 in leukaemia. Finally, the manipulation of Musashi expression is proposed as a potential avenue towards the targeted treatment of specific aggressive stem cell cancers.
KW - Cancer stem cells
KW - RNA binding proteins
KW - Stem cell niche
UR - http://www.scopus.com/inward/record.url?scp=84934441288&partnerID=8YFLogxK
U2 - 10.1007/978-94-007-6621-1_13
DO - 10.1007/978-94-007-6621-1_13
M3 - Chapter
SN - 9789400766204
VL - 786
T3 - Advances in Experimental Medicine and Biology
SP - 233
EP - 245
BT - Transcriptional and Translational Regulation of Stem Cells
A2 - Hime, Gary
A2 - Abud, Helen
PB - Springer
CY - Dordrecht, Netherlands
ER -