The non-pathogenic Australian rabbit calicivirus RCV-A1 provides temporal and partial cross protection to lethal Rabbit Haemorrhagic Disease Virus infection which is not dependent on antibody titres

Tanja Strive, P Elsworth, John D. Wright, John Kovaliski, Lorenzo Capucci

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    The endemic non-pathogenic Australian rabbit calicivirus RCV-A1 is known to provide some cross protection to lethal infection with the closely related Rabbit Haemorrhagic Disease Virus (RHDV). Despite its obvious negative impacts on viral biocontrol of introduced European rabbits in Australia, little is known about the extent and mechanisms of this cross protection. In this study 46 rabbits from a colony naturally infected with RCV-A1 were exposed to RHDV. Survival rates and survival times did not correlate with titres of serum antibodies specific to RCV-A1 or cross reacting to RHDV, but were instead influenced by the time between infection with the two viruses, demonstrating for the first time that the cross protection to lethal RHDV infection is transient. These findings are an important step towards a better understanding of the complex interactions of co-occurring pathogenic and non-pathogenic lagoviruses.
    Original languageEnglish
    Pages (from-to)1-11
    Number of pages11
    JournalVeterinary Research
    Volume44
    Issue number1
    DOIs
    Publication statusPublished - 2013

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    Rabbit Haemorrhagic Disease Virus
    Rabbit hemorrhagic disease virus
    Cross Protection
    Virus Diseases
    Rabbits
    antibodies
    Antibodies
    Lagovirus
    infection
    rabbits
    Infection
    Viruses
    biological control
    survival rate
    Serum
    viruses

    Cite this

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    title = "The non-pathogenic Australian rabbit calicivirus RCV-A1 provides temporal and partial cross protection to lethal Rabbit Haemorrhagic Disease Virus infection which is not dependent on antibody titres",
    abstract = "The endemic non-pathogenic Australian rabbit calicivirus RCV-A1 is known to provide some cross protection to lethal infection with the closely related Rabbit Haemorrhagic Disease Virus (RHDV). Despite its obvious negative impacts on viral biocontrol of introduced European rabbits in Australia, little is known about the extent and mechanisms of this cross protection. In this study 46 rabbits from a colony naturally infected with RCV-A1 were exposed to RHDV. Survival rates and survival times did not correlate with titres of serum antibodies specific to RCV-A1 or cross reacting to RHDV, but were instead influenced by the time between infection with the two viruses, demonstrating for the first time that the cross protection to lethal RHDV infection is transient. These findings are an important step towards a better understanding of the complex interactions of co-occurring pathogenic and non-pathogenic lagoviruses.",
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    The non-pathogenic Australian rabbit calicivirus RCV-A1 provides temporal and partial cross protection to lethal Rabbit Haemorrhagic Disease Virus infection which is not dependent on antibody titres. / Strive, Tanja; Elsworth, P; Wright, John D.; Kovaliski, John; Capucci, Lorenzo.

    In: Veterinary Research, Vol. 44, No. 1, 2013, p. 1-11.

    Research output: Contribution to journalArticle

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