TY - JOUR
T1 - The Relationship between Progression in Axial Length/Corneal Radius of Curvature Ratio and Spherical Equivalent Refractive Error in Myopia
AU - Jong, Monica
AU - Sankaridurg, Padmaja
AU - Naduvilath, Thomas John
AU - Li, Wayne
AU - He, Mingguang
N1 - Publisher Copyright:
© 2018 Lippincott Williams & Wilkins.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - SIGNIFICANCE: This study demonstrates that mean axial length/corneal radius of curvature ratio (AL/CR) can be used to detect low and high myopia but cannot clinically monitor myopia progression because the relationship between AL/CR and progression in myopia is different between low and high myopia.PURPOSE: The purpose of this study was to investigate the relationship of AL/CR with magnitude and progression of myopia.METHODS: Retrospective analysis was conducted comparing the right eyes of those with high myopia (n = 308; age, 7 to 16 years; myopia sphere, -6.00 diopters or worse) with those with low myopia (n = 732; age, 7 to 16 years; myopia sphere, between -0.50 and -3.50 diopters; cylinder, ≤1.00 diopters). Baseline axial length, corneal radii of curvature, and cycloplegic objective refraction were analyzed. Myopia progression in the low-myopia group at 6- and 12-month follow-up was measured, and the differences in slopes of AL/CR were compared for slow (<0.75 diopters) and fast progressing (≥0.75 diopters).RESULTS: Mean AL/CR values were significantly different (P < .001) between high myopia (3.46 ± 0.10) and low myopia (3.16 ± 0.07). In high and low myopia, slopes of axial length versus corneal curvature radius were not significantly different (P > .05), and slopes of AL/CR versus spherical equivalent were significantly different after adjusting for spherical equivalent and age (P < .05). Slopes of AL/CR progression and spherical equivalent progression were significantly different in low myopia between fast and slow progressing (P < .001), but the relationship between progression in AL/CR and progression in spherical equivalent was not strong.CONCLUSIONS: The AL/CR can be used to classify different grades of myopia, but it is not useful in determining the magnitude of myopia or monitoring progression because AL/CR is not linearly related to spherical equivalent and because progression in AL/CR is not strongly related to spherical equivalent progression.
AB - SIGNIFICANCE: This study demonstrates that mean axial length/corneal radius of curvature ratio (AL/CR) can be used to detect low and high myopia but cannot clinically monitor myopia progression because the relationship between AL/CR and progression in myopia is different between low and high myopia.PURPOSE: The purpose of this study was to investigate the relationship of AL/CR with magnitude and progression of myopia.METHODS: Retrospective analysis was conducted comparing the right eyes of those with high myopia (n = 308; age, 7 to 16 years; myopia sphere, -6.00 diopters or worse) with those with low myopia (n = 732; age, 7 to 16 years; myopia sphere, between -0.50 and -3.50 diopters; cylinder, ≤1.00 diopters). Baseline axial length, corneal radii of curvature, and cycloplegic objective refraction were analyzed. Myopia progression in the low-myopia group at 6- and 12-month follow-up was measured, and the differences in slopes of AL/CR were compared for slow (<0.75 diopters) and fast progressing (≥0.75 diopters).RESULTS: Mean AL/CR values were significantly different (P < .001) between high myopia (3.46 ± 0.10) and low myopia (3.16 ± 0.07). In high and low myopia, slopes of axial length versus corneal curvature radius were not significantly different (P > .05), and slopes of AL/CR versus spherical equivalent were significantly different after adjusting for spherical equivalent and age (P < .05). Slopes of AL/CR progression and spherical equivalent progression were significantly different in low myopia between fast and slow progressing (P < .001), but the relationship between progression in AL/CR and progression in spherical equivalent was not strong.CONCLUSIONS: The AL/CR can be used to classify different grades of myopia, but it is not useful in determining the magnitude of myopia or monitoring progression because AL/CR is not linearly related to spherical equivalent and because progression in AL/CR is not strongly related to spherical equivalent progression.
KW - Adolescent
KW - Axial Length, Eye/pathology
KW - Child
KW - Cornea/pathology
KW - Disease Progression
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Mydriatics/administration & dosage
KW - Myopia/diagnosis
KW - Myopia, Degenerative/diagnosis
KW - Refraction, Ocular/physiology
KW - Retrospective Studies
KW - Vision Tests
UR - http://www.scopus.com/inward/record.url?scp=85054330779&partnerID=8YFLogxK
U2 - 10.1097/OPX.0000000000001281
DO - 10.1097/OPX.0000000000001281
M3 - Article
C2 - 30247237
SN - 0093-7002
VL - 95
SP - 921
EP - 929
JO - Optometry and Vision Science
JF - Optometry and Vision Science
IS - 10
ER -