The relationship of plasma creatinine (as eGFR) and high-sensitivity cardiac troponin and NT-proBNP concentrations in a hospital and community outpatient population

Julia M. Potter, Aaron J. Simpson, Jennifer Kerrigan, Emma Southcott, Marie M. Salib, Gus Koerbin, Peter E. Hickman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives While persons with overt renal failure have a well-described rise in troponin and NT-proBNP, it is less well described what the relationship is between cardiac markers and persons with impaired renal function, not requiring dialysis. Design & methods We have collected ALL samples referred to our pathology practice over a 24 h period and measured hs-cTnI, hs-cTnT, NT-proBNP, calculated the eGFR, and related our measurements to clinical outcomes. Results For both men and women, for all of hs-cTnI, hs-cTnT and NT-proBNP, there was a graded response, as renal function worsened, the concentration of the cardiac marker increased. Conclusions There is a graded inverse relationship between eGFR and the concentrations of hs-cTnI, hs-cTnT and NT-proBNP. For women only there appeared to be an increase in mortality at lowest eGFR.

Original languageEnglish
Pages (from-to)813-815
Number of pages3
JournalClinical Biochemistry
Volume50
Issue number15
DOIs
Publication statusPublished - 1 Oct 2017

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Troponin
Creatinine
Outpatients
Plasmas
Population
Kidney
Dialysis
Pathology
Renal Insufficiency
Mortality
pro-brain natriuretic peptide (1-76)

Cite this

Potter, Julia M. ; Simpson, Aaron J. ; Kerrigan, Jennifer ; Southcott, Emma ; Salib, Marie M. ; Koerbin, Gus ; Hickman, Peter E. / The relationship of plasma creatinine (as eGFR) and high-sensitivity cardiac troponin and NT-proBNP concentrations in a hospital and community outpatient population. In: Clinical Biochemistry. 2017 ; Vol. 50, No. 15. pp. 813-815.
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The relationship of plasma creatinine (as eGFR) and high-sensitivity cardiac troponin and NT-proBNP concentrations in a hospital and community outpatient population. / Potter, Julia M.; Simpson, Aaron J.; Kerrigan, Jennifer; Southcott, Emma; Salib, Marie M.; Koerbin, Gus; Hickman, Peter E.

In: Clinical Biochemistry, Vol. 50, No. 15, 01.10.2017, p. 813-815.

Research output: Contribution to journalArticle

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AU - Potter, Julia M.

AU - Simpson, Aaron J.

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AU - Southcott, Emma

AU - Salib, Marie M.

AU - Koerbin, Gus

AU - Hickman, Peter E.

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N2 - Objectives While persons with overt renal failure have a well-described rise in troponin and NT-proBNP, it is less well described what the relationship is between cardiac markers and persons with impaired renal function, not requiring dialysis. Design & methods We have collected ALL samples referred to our pathology practice over a 24 h period and measured hs-cTnI, hs-cTnT, NT-proBNP, calculated the eGFR, and related our measurements to clinical outcomes. Results For both men and women, for all of hs-cTnI, hs-cTnT and NT-proBNP, there was a graded response, as renal function worsened, the concentration of the cardiac marker increased. Conclusions There is a graded inverse relationship between eGFR and the concentrations of hs-cTnI, hs-cTnT and NT-proBNP. For women only there appeared to be an increase in mortality at lowest eGFR.

AB - Objectives While persons with overt renal failure have a well-described rise in troponin and NT-proBNP, it is less well described what the relationship is between cardiac markers and persons with impaired renal function, not requiring dialysis. Design & methods We have collected ALL samples referred to our pathology practice over a 24 h period and measured hs-cTnI, hs-cTnT, NT-proBNP, calculated the eGFR, and related our measurements to clinical outcomes. Results For both men and women, for all of hs-cTnI, hs-cTnT and NT-proBNP, there was a graded response, as renal function worsened, the concentration of the cardiac marker increased. Conclusions There is a graded inverse relationship between eGFR and the concentrations of hs-cTnI, hs-cTnT and NT-proBNP. For women only there appeared to be an increase in mortality at lowest eGFR.

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