The societal burden of haemophilia A. III – The potential impact of emicizumab on costs of haemophilia A in Australia

Laurie Brown, Hai Anh La, Jinjing Li, Matthias Brunner, Martin Snoke, Annette M Kerr

Research output: Contribution to journalArticle

Abstract

Introduction
Emicizumab is a humanized monoclonal modified IgG4 antibody with bispecific antibody structure bridging Factor IXa and Factor X. Emicizumab has demonstrated efficacy and safety in adults, adolescents and paediatrics with HA, with or without inhibitors to Factor VIII (FVIII). There is currently no evidence that reports on the potential impact of the introduction of emicizumab on the societal costs of haemophilia A (HA). The purpose of this study was to explore the cost impact associated with the introduction of emicizumab on the current societal costs of people with HA (PwHA) in Australia.

Methods
We conducted an analysis of the impact of emicizumab on societal costs, based on changes in the direct and indirect costs incurred by PwHA. Potential impacts of emicizumab on outcomes in PwHA were modelled based on HAVEN 1, HAVEN 2 and HAVEN 3 studies. We assumed that eligible PwHA commenced use of emicizumab on 1 January 2018. The impact of emicizumab on costs of HA in Australia males was then estimated for the 12‐month period to 31 December 2018.

Results
Overall, uptake of emicizumab in its first year of use reduces annual costs associated with moderate/severe HA by AUD$69.197M (62.3%). This reflects 64.2% reduction in the cost of FVIII blood products and 92% reduction in cost of bypassing agents.

Conclusion
The cost of emicizumab is likely to offset some or all of the projected reductions in treatment costs. However, we also found 30.7% reduction in non‐treatment direct costs (AUD$3.771M) and 19.1% reduction in indirect costs (AUD$2.732M).
Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalHaemophilia
Volume26
Issue number5
DOIs
Publication statusPublished - 16 Sep 2020

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