Thiopurines for inflammatory bowel disease

Role of pharmacogenetics

A. F Y Al Hadithy, Mark Naunton, J. R B J Brouwers

Research output: Contribution to journalReview article

Abstract

There is a growing interest in the use of thiopurines for inflammatory bowel disease. Pharmacogenetic insights suggest that the genetic profile of thiopurine S-methyltransferase and inosine triphosphate pyrophosphatase may affect the clinical response to thiopurines. This is a review on the pharmacogenetics of these enzymes and highlights difficulties that impede prior-to-treat pharmacogenetic testing for the thiopurines in practice.

Original languageEnglish
Pages (from-to)213-215
Number of pages3
JournalJournal of Pharmacy Practice and Research
Volume35
Issue number3
Publication statusPublished - 1 Sep 2005
Externally publishedYes

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Pharmacogenetics
thiopurine methyltransferase
Inflammatory Bowel Diseases
Pyrophosphatases
Inosine Triphosphate
Enzymes
Testing
Pharmacogenomic Testing

Cite this

Al Hadithy, A. F Y ; Naunton, Mark ; Brouwers, J. R B J. / Thiopurines for inflammatory bowel disease : Role of pharmacogenetics. In: Journal of Pharmacy Practice and Research. 2005 ; Vol. 35, No. 3. pp. 213-215.
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Thiopurines for inflammatory bowel disease : Role of pharmacogenetics. / Al Hadithy, A. F Y; Naunton, Mark; Brouwers, J. R B J.

In: Journal of Pharmacy Practice and Research, Vol. 35, No. 3, 01.09.2005, p. 213-215.

Research output: Contribution to journalReview article

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