Thiopurines for inflammatory bowel disease: Role of pharmacogenetics

A. F Y Al Hadithy, Mark Naunton, J. R B J Brouwers

Research output: Contribution to journalReview articlepeer-review


There is a growing interest in the use of thiopurines for inflammatory bowel disease. Pharmacogenetic insights suggest that the genetic profile of thiopurine S-methyltransferase and inosine triphosphate pyrophosphatase may affect the clinical response to thiopurines. This is a review on the pharmacogenetics of these enzymes and highlights difficulties that impede prior-to-treat pharmacogenetic testing for the thiopurines in practice.

Original languageEnglish
Pages (from-to)213-215
Number of pages3
JournalJournal of Pharmacy Practice and Research
Issue number3
Publication statusPublished - 1 Sept 2005
Externally publishedYes


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