Thyroarytenoid muscle electrical activity during spontaneous apneas in preterm lambs

Sylvain Renolleau, Patrick Letourneau, Théophile Niyonsenga, Jean Paul Praud, Bruno Gagné

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Laryngeal dynamics plays a major role during perinatal life, a period of respiratory control immaturity. Continuous electromyographic (EMG) activity of a laryngeal adductor muscle (thyroarytenoid [TA] muscle), was recently observed throughout provoked central apneas, either isolated or during induced periodic breathing, in full-term lambs. The aim of the present study was to test if continuous TA EMG activity was also present during spontaneous apneas in nonsedated preterm lambs. We studied 7 premature lambs (term 131 ± 1 d of postconceptional age). Premature birth was induced after acceleration of fetal lung maturation. Electrodes for diaphragm, inferior pharyngeal constrictor (IPC), and TA electromyograms, electrocardiogram, electroencephalogram, eye movement, and airflow recordings were implanted. Radiotelemetry recordings were repeated from 135 to 149 ± 8 d of postconceptional age. A total of 2,088 apneas (2,020 central and 68 mixed) ≥ 3 s were recorded in the lambs, including 57 epochs of periodic breathing. Continuous TA EMG activity was present throughout 88.4% of all apneas and 98.4% of apneas during periodic breathing, regardless of the sleep stage. These results suggest that active glottic closure is frequent during spontaneous central apneas in this model of prematurity. This unique model will allow us to study controlling mechanisms and consequences of glottic closure during neonatal apneas.

Original languageEnglish
Pages (from-to)1396-1404
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume159
Issue number5 I
DOIs
Publication statusPublished - 1 Jan 1999
Externally publishedYes

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Laryngeal Muscles
Apnea
Central Sleep Apnea
Respiration
Tongue
Sleep Stages
Premature Birth
Electromyography
Eye Movements
Diaphragm
Electroencephalography
Electrocardiography
Electrodes
Lung

Cite this

Renolleau, Sylvain ; Letourneau, Patrick ; Niyonsenga, Théophile ; Praud, Jean Paul ; Gagné, Bruno. / Thyroarytenoid muscle electrical activity during spontaneous apneas in preterm lambs. In: American Journal of Respiratory and Critical Care Medicine. 1999 ; Vol. 159, No. 5 I. pp. 1396-1404.
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Thyroarytenoid muscle electrical activity during spontaneous apneas in preterm lambs. / Renolleau, Sylvain; Letourneau, Patrick; Niyonsenga, Théophile; Praud, Jean Paul; Gagné, Bruno.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 159, No. 5 I, 01.01.1999, p. 1396-1404.

Research output: Contribution to journalArticle

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