Time course of haemoglobin mass during 21 days live high: train low simulated altitude

Sally A. Clark; M. J. Quod; M. A. Clark; D. T. Martin; P. U. Saunders; C. J. Gore

doi:10.1007/s00421-009-1027-4

Time course of haemoglobin mass during 21 days live high: train low simulated altitude

Sally A. Clark, M. J. Quod, M. A. Clark, D. T. Martin, P. U. Saunders, C. J. Gore

Research output: Contribution to journal › Article › peer-review

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Abstract

The aim of this study was to determine the time course of changes in haemoglobin mass (Hb_mass) in well-trained cyclists in response to live high:train low (LHTL). Twelve well-trained male cyclists participated in a 3-week LHTL protocol comprising 3,000 m simulated altitude for ∼14 h/day. Prior to LHTL duplicate baseline measurements were made of Hb_mass, maximal oxygen consumption (VO_2max) and serum erythropoietin (sEPO). Hb_mass was measured weekly during LHTL and twice in the week thereafter. There was a 3.3% increase in Hb_mass and no change in VO_2max after LHTL. The mean Hb_mass increased at a rate of ∼1% per week and this was maintained in the week after cessation of LHTL. The sEPO concentration peaked after two nights of LHTL but there was only a trivial correlation (r = 0.04, P = 0.89) between the increase in sEPO and the increase in Hb_mass. Athletes seeking to gain erythropoietic benefits from moderate altitude need to spend >12 h/day in hypoxia.

Original language	English
Pages (from-to)	399-406
Number of pages	8
Journal	European Journal of Applied Physiology
Volume	106
Issue number	3
DOIs	https://doi.org/10.1007/s00421-009-1027-4
Publication status	Published - 2009
Externally published	Yes

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title = "Time course of haemoglobin mass during 21 days live high: train low simulated altitude",

abstract = "The aim of this study was to determine the time course of changes in haemoglobin mass (Hbmass) in well-trained cyclists in response to live high:train low (LHTL). Twelve well-trained male cyclists participated in a 3-week LHTL protocol comprising 3,000 m simulated altitude for ∼14 h/day. Prior to LHTL duplicate baseline measurements were made of Hbmass, maximal oxygen consumption (VO2max) and serum erythropoietin (sEPO). Hbmass was measured weekly during LHTL and twice in the week thereafter. There was a 3.3% increase in Hbmass and no change in VO2max after LHTL. The mean Hbmass increased at a rate of ∼1% per week and this was maintained in the week after cessation of LHTL. The sEPO concentration peaked after two nights of LHTL but there was only a trivial correlation (r = 0.04, P = 0.89) between the increase in sEPO and the increase in Hbmass. Athletes seeking to gain erythropoietic benefits from moderate altitude need to spend >12 h/day in hypoxia.",

keywords = "Haemoglobin mass, Simulated altitude",

author = "Clark, {Sally A.} and Quod, {M. J.} and Clark, {M. A.} and Martin, {D. T.} and Saunders, {P. U.} and Gore, {C. J.}",

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T2 - train low simulated altitude

AU - Clark, Sally A.

AU - Quod, M. J.

AU - Clark, M. A.

AU - Martin, D. T.

AU - Saunders, P. U.

AU - Gore, C. J.

PY - 2009

Y1 - 2009

N2 - The aim of this study was to determine the time course of changes in haemoglobin mass (Hbmass) in well-trained cyclists in response to live high:train low (LHTL). Twelve well-trained male cyclists participated in a 3-week LHTL protocol comprising 3,000 m simulated altitude for ∼14 h/day. Prior to LHTL duplicate baseline measurements were made of Hbmass, maximal oxygen consumption (VO2max) and serum erythropoietin (sEPO). Hbmass was measured weekly during LHTL and twice in the week thereafter. There was a 3.3% increase in Hbmass and no change in VO2max after LHTL. The mean Hbmass increased at a rate of ∼1% per week and this was maintained in the week after cessation of LHTL. The sEPO concentration peaked after two nights of LHTL but there was only a trivial correlation (r = 0.04, P = 0.89) between the increase in sEPO and the increase in Hbmass. Athletes seeking to gain erythropoietic benefits from moderate altitude need to spend >12 h/day in hypoxia.

AB - The aim of this study was to determine the time course of changes in haemoglobin mass (Hbmass) in well-trained cyclists in response to live high:train low (LHTL). Twelve well-trained male cyclists participated in a 3-week LHTL protocol comprising 3,000 m simulated altitude for ∼14 h/day. Prior to LHTL duplicate baseline measurements were made of Hbmass, maximal oxygen consumption (VO2max) and serum erythropoietin (sEPO). Hbmass was measured weekly during LHTL and twice in the week thereafter. There was a 3.3% increase in Hbmass and no change in VO2max after LHTL. The mean Hbmass increased at a rate of ∼1% per week and this was maintained in the week after cessation of LHTL. The sEPO concentration peaked after two nights of LHTL but there was only a trivial correlation (r = 0.04, P = 0.89) between the increase in sEPO and the increase in Hbmass. Athletes seeking to gain erythropoietic benefits from moderate altitude need to spend >12 h/day in hypoxia.

KW - Haemoglobin mass

KW - Simulated altitude

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JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

IS - 3

ER -

Time course of haemoglobin mass during 21 days live high: train low simulated altitude

Abstract

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