Tocotrienols, health and ageing: A systematic review

Ekavi Georgousopoulou, Demosthenes Panagiotakos, Duane MELLOR, Nenad NAUMOVSKI

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives A systematic review of studies was undertaken to evaluate the potential effect of intake of tocotrienols or circulating levels of tocotrienols on parameters associated with successful ageing, specifically in relation to cognitive function, osteoporosis and DNA damage. Methods Following PRISMA guidelines a systematic review of epidemiological observational studies and clinical trials was undertaken. Inclusion criteria included all English language publications in the databases PubMed and Scopus, through to the end of July 2016. Results Evidence from prospective and case-control studies suggested that increased blood levels of tocotrienols were associated with favorable cognitive function outcomes. A clinical trial of tocotrienol supplementation for 6 months suggested a beneficial effect of intake on DNA damage rates, but only in elderly people. Regarding osteoporosis, only in vitro studies with cultures of human bone cells were identified, and these demonstrated significant inhibition of osteoclast activity and promotion of osteoblast activity. Conclusions Research in middle-aged and elderly humans suggests that tocotrienols have a potential beneficial anti-ageing action with respect to cognitive impairment and DNA damage. Clinical trials are required to elucidate these effects.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalMaturitas
Volume95
DOIs
Publication statusPublished - 2017

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Tocotrienols
Aging of materials
Health
DNA Damage
Clinical Trials
Cognition
Osteoporosis
DNA
Osteoblasts
Osteoclasts
PubMed
Observational Studies
Publications
Case-Control Studies
Epidemiologic Studies
Bone
Blood
Language
Databases
Guidelines

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Georgousopoulou, Ekavi ; Panagiotakos, Demosthenes ; MELLOR, Duane ; NAUMOVSKI, Nenad. / Tocotrienols, health and ageing: A systematic review. In: Maturitas. 2017 ; Vol. 95. pp. 55-60.
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Tocotrienols, health and ageing: A systematic review. / Georgousopoulou, Ekavi; Panagiotakos, Demosthenes; MELLOR, Duane; NAUMOVSKI, Nenad.

In: Maturitas, Vol. 95, 2017, p. 55-60.

Research output: Contribution to journalArticle

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AU - Georgousopoulou, Ekavi

AU - Panagiotakos, Demosthenes

AU - MELLOR, Duane

AU - NAUMOVSKI, Nenad

PY - 2017

Y1 - 2017

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AB - Objectives A systematic review of studies was undertaken to evaluate the potential effect of intake of tocotrienols or circulating levels of tocotrienols on parameters associated with successful ageing, specifically in relation to cognitive function, osteoporosis and DNA damage. Methods Following PRISMA guidelines a systematic review of epidemiological observational studies and clinical trials was undertaken. Inclusion criteria included all English language publications in the databases PubMed and Scopus, through to the end of July 2016. Results Evidence from prospective and case-control studies suggested that increased blood levels of tocotrienols were associated with favorable cognitive function outcomes. A clinical trial of tocotrienol supplementation for 6 months suggested a beneficial effect of intake on DNA damage rates, but only in elderly people. Regarding osteoporosis, only in vitro studies with cultures of human bone cells were identified, and these demonstrated significant inhibition of osteoclast activity and promotion of osteoblast activity. Conclusions Research in middle-aged and elderly humans suggests that tocotrienols have a potential beneficial anti-ageing action with respect to cognitive impairment and DNA damage. Clinical trials are required to elucidate these effects.

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