Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes

Catherine Paquet, Sarah Propsting, Mark DANIEL

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes. Design: Fasting values for glucose and insulin were used to estimate insulin resistance by homeostasis model assessment (HOMA-IR). Intakes of n-3 fatty acids and SFA were computed from dietary food and drink data obtained using 3 d food records. Associations between HOMA-IR and dietary n-3 and SFA consumption were tested using linear regression models accounting for age, sex, community, education, physical activity, waist circumference, fibre, protein and carbohydrate intakes, and HDL-cholesterol and TAG concentrations.Setting: Rural Okanagan region of British Columbia, Canada.
Subjects: On-reserve First Nation individuals (Interior Salishan) aged 18 years and over, recruited for community-based diabetes screening and determined to be normoglycaemic (n 126).Results: HOMA-IR was negatively associated with dietary n-3 fatty acid intake (β = −0·22; 95 % CI −0·39, −0·04; P = 0·016) and positively associated with dietary SFA intake (β = 0·34; 95 % CI 0·15, 0·53; P = 0·0 0 1).Conclusions: Intake of dietary n-3 fatty acids may be protective against whereas SFA intake may promote insulin resistance in this high-risk Canadian First Nation sample. Reduced dietary SFA intake and greater n-3 fatty acid intake may assist the prevention of glycaemic disease among First Nations peoples. More rigorous, controlled trials are required to test whether dietary supplementation with n-3 fatty acids in natural or supplement-based form might reduce diabetes risk in high-risk aboriginal groups.
Original languageEnglish
Pages (from-to)1337-1341
Number of pages5
JournalPublic Health Nutrition
Volume17
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Omega-3 Fatty Acids
Type 2 Diabetes Mellitus
Insulin Resistance
Linear Models
Food
British Columbia
Sex Education
Waist Circumference
Dietary Supplements
HDL Cholesterol
Canada
Fasting
Homeostasis
Carbohydrates
Insulin
Glucose
Proteins

Cite this

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title = "Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes",
abstract = "Objective: The present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes. Design: Fasting values for glucose and insulin were used to estimate insulin resistance by homeostasis model assessment (HOMA-IR). Intakes of n-3 fatty acids and SFA were computed from dietary food and drink data obtained using 3 d food records. Associations between HOMA-IR and dietary n-3 and SFA consumption were tested using linear regression models accounting for age, sex, community, education, physical activity, waist circumference, fibre, protein and carbohydrate intakes, and HDL-cholesterol and TAG concentrations.Setting: Rural Okanagan region of British Columbia, Canada.Subjects: On-reserve First Nation individuals (Interior Salishan) aged 18 years and over, recruited for community-based diabetes screening and determined to be normoglycaemic (n 126).Results: HOMA-IR was negatively associated with dietary n-3 fatty acid intake (β = −0·22; 95 {\%} CI −0·39, −0·04; P = 0·016) and positively associated with dietary SFA intake (β = 0·34; 95 {\%} CI 0·15, 0·53; P = 0·0 0 1).Conclusions: Intake of dietary n-3 fatty acids may be protective against whereas SFA intake may promote insulin resistance in this high-risk Canadian First Nation sample. Reduced dietary SFA intake and greater n-3 fatty acid intake may assist the prevention of glycaemic disease among First Nations peoples. More rigorous, controlled trials are required to test whether dietary supplementation with n-3 fatty acids in natural or supplement-based form might reduce diabetes risk in high-risk aboriginal groups.",
author = "Catherine Paquet and Sarah Propsting and Mark DANIEL",
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Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes. / Paquet, Catherine; Propsting, Sarah; DANIEL, Mark.

In: Public Health Nutrition, Vol. 17, No. 6, 2014, p. 1337-1341.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes

AU - Paquet, Catherine

AU - Propsting, Sarah

AU - DANIEL, Mark

PY - 2014

Y1 - 2014

N2 - Objective: The present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes. Design: Fasting values for glucose and insulin were used to estimate insulin resistance by homeostasis model assessment (HOMA-IR). Intakes of n-3 fatty acids and SFA were computed from dietary food and drink data obtained using 3 d food records. Associations between HOMA-IR and dietary n-3 and SFA consumption were tested using linear regression models accounting for age, sex, community, education, physical activity, waist circumference, fibre, protein and carbohydrate intakes, and HDL-cholesterol and TAG concentrations.Setting: Rural Okanagan region of British Columbia, Canada.Subjects: On-reserve First Nation individuals (Interior Salishan) aged 18 years and over, recruited for community-based diabetes screening and determined to be normoglycaemic (n 126).Results: HOMA-IR was negatively associated with dietary n-3 fatty acid intake (β = −0·22; 95 % CI −0·39, −0·04; P = 0·016) and positively associated with dietary SFA intake (β = 0·34; 95 % CI 0·15, 0·53; P = 0·0 0 1).Conclusions: Intake of dietary n-3 fatty acids may be protective against whereas SFA intake may promote insulin resistance in this high-risk Canadian First Nation sample. Reduced dietary SFA intake and greater n-3 fatty acid intake may assist the prevention of glycaemic disease among First Nations peoples. More rigorous, controlled trials are required to test whether dietary supplementation with n-3 fatty acids in natural or supplement-based form might reduce diabetes risk in high-risk aboriginal groups.

AB - Objective: The present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes. Design: Fasting values for glucose and insulin were used to estimate insulin resistance by homeostasis model assessment (HOMA-IR). Intakes of n-3 fatty acids and SFA were computed from dietary food and drink data obtained using 3 d food records. Associations between HOMA-IR and dietary n-3 and SFA consumption were tested using linear regression models accounting for age, sex, community, education, physical activity, waist circumference, fibre, protein and carbohydrate intakes, and HDL-cholesterol and TAG concentrations.Setting: Rural Okanagan region of British Columbia, Canada.Subjects: On-reserve First Nation individuals (Interior Salishan) aged 18 years and over, recruited for community-based diabetes screening and determined to be normoglycaemic (n 126).Results: HOMA-IR was negatively associated with dietary n-3 fatty acid intake (β = −0·22; 95 % CI −0·39, −0·04; P = 0·016) and positively associated with dietary SFA intake (β = 0·34; 95 % CI 0·15, 0·53; P = 0·0 0 1).Conclusions: Intake of dietary n-3 fatty acids may be protective against whereas SFA intake may promote insulin resistance in this high-risk Canadian First Nation sample. Reduced dietary SFA intake and greater n-3 fatty acid intake may assist the prevention of glycaemic disease among First Nations peoples. More rigorous, controlled trials are required to test whether dietary supplementation with n-3 fatty acids in natural or supplement-based form might reduce diabetes risk in high-risk aboriginal groups.

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DO - 10.1017/S1368980013000542

M3 - Article

VL - 17

SP - 1337

EP - 1341

JO - Public Health Nutrition

JF - Public Health Nutrition

SN - 1368-9800

IS - 6

ER -