True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase

Ashraf Ghanem

doi:10.1016/j.chroma.2006.09.043

True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase

Ashraf Ghanem

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A set of racemic N-alkylated barbiturates were investigated for their direct enantioselective HPLC separation on a new chiral stationary phase (CSP) containing cellulose tris(3,5-dimethylphenylcarabamate) immobilized onto silica gel (Chiralpak IB) and its coated version (Chiralcel OD). They were online detected by UV and optical rotation detectors to trace the elution order of their enantiomers. Surprisingly, examples of false and true reversal of the elution order of enantiomers of barbiturates were observed and reported.

Original language	English
Pages (from-to)	329-332
Number of pages	4
Journal	Journal of Chromatography A
Volume	1132
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2006.09.043
Publication status	Published - 3 Nov 2006
Externally published	Yes

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10.1016/j.chroma.2006.09.043

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title = "True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase",

abstract = "A set of racemic N-alkylated barbiturates were investigated for their direct enantioselective HPLC separation on a new chiral stationary phase (CSP) containing cellulose tris(3,5-dimethylphenylcarabamate) immobilized onto silica gel (Chiralpak IB) and its coated version (Chiralcel OD). They were online detected by UV and optical rotation detectors to trace the elution order of their enantiomers. Surprisingly, examples of false and true reversal of the elution order of enantiomers of barbiturates were observed and reported.",

keywords = "Cellulose tris(3,5-dimethylphenylcarbamate), Chiralcel OD, Chiralpak IB, Elution order, Enantioseparation, HPLC, N-alkylated barbiturates",

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doi = "10.1016/j.chroma.2006.09.043",

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AU - Ghanem, Ashraf

PY - 2006/11/3

Y1 - 2006/11/3

N2 - A set of racemic N-alkylated barbiturates were investigated for their direct enantioselective HPLC separation on a new chiral stationary phase (CSP) containing cellulose tris(3,5-dimethylphenylcarabamate) immobilized onto silica gel (Chiralpak IB) and its coated version (Chiralcel OD). They were online detected by UV and optical rotation detectors to trace the elution order of their enantiomers. Surprisingly, examples of false and true reversal of the elution order of enantiomers of barbiturates were observed and reported.

AB - A set of racemic N-alkylated barbiturates were investigated for their direct enantioselective HPLC separation on a new chiral stationary phase (CSP) containing cellulose tris(3,5-dimethylphenylcarabamate) immobilized onto silica gel (Chiralpak IB) and its coated version (Chiralcel OD). They were online detected by UV and optical rotation detectors to trace the elution order of their enantiomers. Surprisingly, examples of false and true reversal of the elution order of enantiomers of barbiturates were observed and reported.

KW - Cellulose tris(3,5-dimethylphenylcarbamate)

KW - Chiralcel OD

KW - Chiralpak IB

KW - Elution order

KW - Enantioseparation

KW - HPLC

KW - N-alkylated barbiturates

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M3 - Article

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AN - SCOPUS:33749531018

SN - 0021-9673

VL - 1132

SP - 329

EP - 332

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - 1-2

ER -

True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase

Abstract

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