True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A set of racemic N-alkylated barbiturates were investigated for their direct enantioselective HPLC separation on a new chiral stationary phase (CSP) containing cellulose tris(3,5-dimethylphenylcarabamate) immobilized onto silica gel (Chiralpak IB) and its coated version (Chiralcel OD). They were online detected by UV and optical rotation detectors to trace the elution order of their enantiomers. Surprisingly, examples of false and true reversal of the elution order of enantiomers of barbiturates were observed and reported.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalJournal of Chromatography A
Volume1132
Issue number1-2
DOIs
Publication statusPublished - 3 Nov 2006
Externally publishedYes

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Barbiturates
Enantiomers
Cellulose
Optical rotation
Optical Rotation
Silica Gel
High Pressure Liquid Chromatography
Detectors
cellulose tris-3,5-dimethylphenyl-carbamate

Cite this

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title = "True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase",
abstract = "A set of racemic N-alkylated barbiturates were investigated for their direct enantioselective HPLC separation on a new chiral stationary phase (CSP) containing cellulose tris(3,5-dimethylphenylcarabamate) immobilized onto silica gel (Chiralpak IB) and its coated version (Chiralcel OD). They were online detected by UV and optical rotation detectors to trace the elution order of their enantiomers. Surprisingly, examples of false and true reversal of the elution order of enantiomers of barbiturates were observed and reported.",
keywords = "Cellulose tris(3,5-dimethylphenylcarbamate), Chiralcel OD, Chiralpak IB, Elution order, Enantioseparation, HPLC, N-alkylated barbiturates",
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True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase. / Ghanem, Ashraf.

In: Journal of Chromatography A, Vol. 1132, No. 1-2, 03.11.2006, p. 329-332.

Research output: Contribution to journalArticle

TY - JOUR

T1 - True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase

AU - Ghanem, Ashraf

PY - 2006/11/3

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N2 - A set of racemic N-alkylated barbiturates were investigated for their direct enantioselective HPLC separation on a new chiral stationary phase (CSP) containing cellulose tris(3,5-dimethylphenylcarabamate) immobilized onto silica gel (Chiralpak IB) and its coated version (Chiralcel OD). They were online detected by UV and optical rotation detectors to trace the elution order of their enantiomers. Surprisingly, examples of false and true reversal of the elution order of enantiomers of barbiturates were observed and reported.

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KW - Chiralpak IB

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KW - Enantioseparation

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