TY - JOUR
T1 - Tuberculosis related disability
T2 - a systematic review and meta-analysis
AU - Alene, Kefyalew Addis
AU - Wangdi, Kinley
AU - Colquhoun, Samantha
AU - Chani, Kudakwashe
AU - Islam, Tauhid
AU - Rahevar, Kalpeshsinh
AU - Morishita, Fukushi
AU - Byrne, Anthony
AU - Clark, Justin
AU - Viney, Kerri
N1 - © 2021. The Author(s).
Funding Information:
This review was funded by the End TB Unit, World Health Organization Regional Office for the Western Pacific, under an Agreement for Performance of Work contract, with Australian National University. In-kind support was provided by the Australian National University, Curtin University, the Telethon Kids Institute, The University of Sydney, and Bond University. KV is supported by a Sidney Sax Early Career Fellowship from the Australian National Health and Medical Research Council (NHMRC), Canberra ACT, Australia (GNT1121611). SC is supported by NHMRC ISER Centre for Research Excellence grant (APP1107393). KAA is funded by NHMRC Investigator Grant (APP1196549). The funders provided no input into the undertaking or reporting of the research.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Background: The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Therefore, we aimed to quantify the prevalence and types of TB-related disabilities. Methods: We performed a systematic review of TB-related disabilities. The pooled prevalence of disabilities was calculated using the inverse variance heterogeneity model. The maps of the proportions of common types of disabilities by country income level were created. Results: We included a total of 131 studies (217,475 patients) that were conducted in 49 countries. The most common type of disabilities were mental health disorders (23.1%), respiratory impairment (20.7%), musculoskeletal impairment (17.1%), hearing impairment (14.5%), visual impairment (9.8%), renal impairment (5.7%), and neurological impairment (1.6%). The prevalence of respiratory impairment (61.2%) and mental health disorders (42.0%) was highest in low-income countries while neurological impairment was highest in lower middle-income countries (25.6%). Drug-resistant TB was associated with respiratory (58.7%), neurological (37.2%), and hearing impairments (25.0%) and mental health disorders (26.0%), respectively. Conclusions: TB-related disabilities were frequently reported. More uniform reporting tools for TB-related disability and further research to better quantify and mitigate it are urgently needed.
AB - Background: The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Therefore, we aimed to quantify the prevalence and types of TB-related disabilities. Methods: We performed a systematic review of TB-related disabilities. The pooled prevalence of disabilities was calculated using the inverse variance heterogeneity model. The maps of the proportions of common types of disabilities by country income level were created. Results: We included a total of 131 studies (217,475 patients) that were conducted in 49 countries. The most common type of disabilities were mental health disorders (23.1%), respiratory impairment (20.7%), musculoskeletal impairment (17.1%), hearing impairment (14.5%), visual impairment (9.8%), renal impairment (5.7%), and neurological impairment (1.6%). The prevalence of respiratory impairment (61.2%) and mental health disorders (42.0%) was highest in low-income countries while neurological impairment was highest in lower middle-income countries (25.6%). Drug-resistant TB was associated with respiratory (58.7%), neurological (37.2%), and hearing impairments (25.0%) and mental health disorders (26.0%), respectively. Conclusions: TB-related disabilities were frequently reported. More uniform reporting tools for TB-related disability and further research to better quantify and mitigate it are urgently needed.
KW - Disabled Persons
KW - Humans
KW - Mental Disorders
KW - Prevalence
KW - Tuberculosis/epidemiology
KW - Tuberculosis, Multidrug-Resistant
KW - Disability
KW - Treatment
KW - Tuberculosis
KW - Impairment
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85114594838&partnerID=8YFLogxK
U2 - 10.1186/s12916-021-02063-9
DO - 10.1186/s12916-021-02063-9
M3 - Article
C2 - 34496845
SN - 1741-7015
VL - 19
SP - 1
EP - 19
JO - BMC Medicine
JF - BMC Medicine
IS - 1
M1 - 203
ER -