We present U-series, Sr-Nd-Pb isotope and trace-element results of a regional study of geochemical systematics across an island arc-continent collision zone in the East Sunda Arc of Indonesia. Samples from four active volcanoes exhibit a striking compositional range from low-K tholeiitic to ultrapotassic, but all are characterised by high 87Sr/86Sr (0.7053-0.7067), radiogenic lead isotope ratios (206Pb/204Pb = 18.99-19.15), low (230Th)/(232Th) (0.66-0.85), and low 143Nd/144Nd (0.51255-0.51272), except for high 143Nd/144Nd (>0.51286) at the volcanic front. Low (230Th)/(232Th) ratios are also found in terrigenous sediments in front of the arc, which, in combination with Sr-Nd-Pb isotopic constraints, indicates that subducted continental material contributes to magma sources in this arc sector. The volcanoes close to the trench show a large excess of 238U over 230Th (up to 80%) and of 226Ra over 230Th (up to 800%). In addition, they are enriched in elements thought to be mobile in hydrous fluids during slab-wedge transfer, such as Ba, Pb, and Sr. In contrast, U-Th-Ra systematics are close to equilibrium in the volcanoes behind the front. Abundance patterns of incompatible trace elements in these rocks are similar to those of the terrigenous sediments, so that, in comparison with the arc-front lavas, they possess low Ba/La, Ba/Th, La/Th, Pb/Ce, and Zr/Nb. Higher concentration levels and less interelement fractionation form conspicuous differences with the front volcanics. Our combined isotopic and trace element data are consistent with three-component mixing whereby a slab-derived hydrous fluid and a siliceous melt are both added to the sub-arc mantle source. The hydrous fluid largely controls the input in the shallow part of the subduction zone, whereas the siliceous melt dominates the flux at deeper levels. Sedimentary material is considered to be the primary source of both. The large U-Th-Ra disequilibria at the front suggests that element transfer is a currently active process associated with present-day subduction of continental material.