Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes

Janine Deakin, Julie Chaumeil, Timothy Hore, Jennifer Marshall Graves

    Research output: Contribution to journalReview article

    43 Citations (Scopus)

    Abstract

    Determining the evolutionary origin of X inactivation mechanisms in mammals requires knowledge of features of X inactivation across all three major mammal lineages; monotremes, marsupials and eutherians. In the past, research into X inactivation in marsupials and monotremes lagged far behind the major advances made in understanding the mechanisms of X inactivation in human and mouse. Fragmentary knowledge of the genic content and sequence of marsupial and monotreme X chromosomes has been alleviated by the recent release of genome sequences for two marsupials and one monotreme. This has lead to a number of important findings, among which is the absence of XIST in marsupials and monotremes, and the surprising finding that X-borne genes in platypus are subject to stochastic transcriptional inhibition rather than whole chromosome inactivation. Availability of sequence data, and new techniques for studying expression and chromatin modification, now make rapid advance possible.
    Original languageEnglish
    Pages (from-to)671-685
    Number of pages15
    JournalChromosome Research
    Volume17
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Marsupialia
    X Chromosome Inactivation
    Mammals
    Platypus
    X Chromosome
    Chromatin
    Chromosomes
    Genome
    Research
    Genes

    Cite this

    Deakin, Janine ; Chaumeil, Julie ; Hore, Timothy ; Marshall Graves, Jennifer. / Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes. In: Chromosome Research. 2009 ; Vol. 17. pp. 671-685.
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    Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes. / Deakin, Janine; Chaumeil, Julie; Hore, Timothy; Marshall Graves, Jennifer.

    In: Chromosome Research, Vol. 17, 2009, p. 671-685.

    Research output: Contribution to journalReview article

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    T1 - Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes

    AU - Deakin, Janine

    AU - Chaumeil, Julie

    AU - Hore, Timothy

    AU - Marshall Graves, Jennifer

    PY - 2009

    Y1 - 2009

    N2 - Determining the evolutionary origin of X inactivation mechanisms in mammals requires knowledge of features of X inactivation across all three major mammal lineages; monotremes, marsupials and eutherians. In the past, research into X inactivation in marsupials and monotremes lagged far behind the major advances made in understanding the mechanisms of X inactivation in human and mouse. Fragmentary knowledge of the genic content and sequence of marsupial and monotreme X chromosomes has been alleviated by the recent release of genome sequences for two marsupials and one monotreme. This has lead to a number of important findings, among which is the absence of XIST in marsupials and monotremes, and the surprising finding that X-borne genes in platypus are subject to stochastic transcriptional inhibition rather than whole chromosome inactivation. Availability of sequence data, and new techniques for studying expression and chromatin modification, now make rapid advance possible.

    AB - Determining the evolutionary origin of X inactivation mechanisms in mammals requires knowledge of features of X inactivation across all three major mammal lineages; monotremes, marsupials and eutherians. In the past, research into X inactivation in marsupials and monotremes lagged far behind the major advances made in understanding the mechanisms of X inactivation in human and mouse. Fragmentary knowledge of the genic content and sequence of marsupial and monotreme X chromosomes has been alleviated by the recent release of genome sequences for two marsupials and one monotreme. This has lead to a number of important findings, among which is the absence of XIST in marsupials and monotremes, and the surprising finding that X-borne genes in platypus are subject to stochastic transcriptional inhibition rather than whole chromosome inactivation. Availability of sequence data, and new techniques for studying expression and chromatin modification, now make rapid advance possible.

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    KW - dosage compensation

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    KW - monotreme.

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