Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon

Rachel Dirks, Jeffrey Richard, Angie FEARON, Alexander Scott, Lauren Koch, Steven Britton, Stuart Warden

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.

Methods
Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.

Results
There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).

Conclusions
Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalBMC Musculoskeletal Disorders
Volume14
Issue number90
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Achilles Tendon
Running
Tendinopathy
Control Groups

Cite this

Dirks, Rachel ; Richard, Jeffrey ; FEARON, Angie ; Scott, Alexander ; Koch, Lauren ; Britton, Steven ; Warden, Stuart. / Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon. In: BMC Musculoskeletal Disorders. 2013 ; Vol. 14, No. 90. pp. 1-5.
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abstract = "The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.MethodsTwenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.ResultsThere were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).ConclusionsUphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans",
author = "Rachel Dirks and Jeffrey Richard and Angie FEARON and Alexander Scott and Lauren Koch and Steven Britton and Stuart Warden",
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Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon. / Dirks, Rachel; Richard, Jeffrey; FEARON, Angie; Scott, Alexander; Koch, Lauren; Britton, Steven; Warden, Stuart.

In: BMC Musculoskeletal Disorders, Vol. 14, No. 90, 2013, p. 1-5.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon

AU - Dirks, Rachel

AU - Richard, Jeffrey

AU - FEARON, Angie

AU - Scott, Alexander

AU - Koch, Lauren

AU - Britton, Steven

AU - Warden, Stuart

PY - 2013

Y1 - 2013

N2 - The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.MethodsTwenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.ResultsThere were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).ConclusionsUphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans

AB - The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.MethodsTwenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.ResultsThere were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).ConclusionsUphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans

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DO - 10.1186/1471-2474-14-90

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JO - BMC Musculoskeletal Disorders

JF - BMC Musculoskeletal Disorders

SN - 1471-2474

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