Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon

Rachel Dirks, Jeffrey Richard, Angie FEARON, Alexander Scott, Lauren Koch, Steven Britton, Stuart Warden

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The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.

Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.

There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).

Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalBMC Musculoskeletal Disorders
Issue number90
Publication statusPublished - 2013
Externally publishedYes


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