Upper Respiratory Symptoms, Gut Health and Mucosal Immunity in Athletes

Candice Colbey, Amanda J. Cox, David B. Pyne, Ping Zhang, Allan W. Cripps, Nicholas P. West

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Upper respiratory symptoms remain the most common illness in athletes. Upper respiratory symptoms during heavy training and competition may impair performance. Preventing illness is the primary reason for the use of supplements, such as probiotics and prebiotics, for maintaining or promoting gut health and immune function. While exercise-induced perturbations in the immune system may increase susceptibility to illness and infection, growing evidence indicates that upper respiratory symptoms are related to a breakdown in the homeostatic regulation of the mucosal immune system of the airways. Balancing protection of the respiratory tract with normal physiological functioning requires dynamic orchestration between a wide array of immune parameters. The intestinal microbiota regulates extra-intestinal immunity via the common mucosal immune system and new evidence implicates the microbiota of the nose, mouth and respiratory tract in upper respiratory symptoms. Omics’ approaches now facilitate comprehensive profiling at the molecular and proteomic levels to reveal new pathways and molecules of immune regulation. New targets may provide for personalised nutritional and training interventions to maintain athlete health.

    Original languageEnglish
    Pages (from-to)65-77
    Number of pages13
    JournalSports Medicine
    Volume48
    DOIs
    Publication statusPublished - 2018

    Fingerprint

    Mucosal Immunity
    Athletes
    Immune System
    Respiratory System
    Health
    Prebiotics
    Microbiota
    Probiotics
    Nose
    Proteomics
    Mouth
    Immunity
    Exercise
    Infection

    Cite this

    Colbey, Candice ; Cox, Amanda J. ; Pyne, David B. ; Zhang, Ping ; Cripps, Allan W. ; West, Nicholas P. / Upper Respiratory Symptoms, Gut Health and Mucosal Immunity in Athletes. In: Sports Medicine. 2018 ; Vol. 48. pp. 65-77.
    @article{ab6d61bec3b64b9bace730d1feb3141e,
    title = "Upper Respiratory Symptoms, Gut Health and Mucosal Immunity in Athletes",
    abstract = "Upper respiratory symptoms remain the most common illness in athletes. Upper respiratory symptoms during heavy training and competition may impair performance. Preventing illness is the primary reason for the use of supplements, such as probiotics and prebiotics, for maintaining or promoting gut health and immune function. While exercise-induced perturbations in the immune system may increase susceptibility to illness and infection, growing evidence indicates that upper respiratory symptoms are related to a breakdown in the homeostatic regulation of the mucosal immune system of the airways. Balancing protection of the respiratory tract with normal physiological functioning requires dynamic orchestration between a wide array of immune parameters. The intestinal microbiota regulates extra-intestinal immunity via the common mucosal immune system and new evidence implicates the microbiota of the nose, mouth and respiratory tract in upper respiratory symptoms. Omics’ approaches now facilitate comprehensive profiling at the molecular and proteomic levels to reveal new pathways and molecules of immune regulation. New targets may provide for personalised nutritional and training interventions to maintain athlete health.",
    author = "Candice Colbey and Cox, {Amanda J.} and Pyne, {David B.} and Ping Zhang and Cripps, {Allan W.} and West, {Nicholas P.}",
    year = "2018",
    doi = "10.1007/s40279-017-0846-4",
    language = "English",
    volume = "48",
    pages = "65--77",
    journal = "Sports Medicine",
    issn = "0112-1642",
    publisher = "Springer",

    }

    Upper Respiratory Symptoms, Gut Health and Mucosal Immunity in Athletes. / Colbey, Candice; Cox, Amanda J.; Pyne, David B.; Zhang, Ping; Cripps, Allan W.; West, Nicholas P.

    In: Sports Medicine, Vol. 48, 2018, p. 65-77.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Upper Respiratory Symptoms, Gut Health and Mucosal Immunity in Athletes

    AU - Colbey, Candice

    AU - Cox, Amanda J.

    AU - Pyne, David B.

    AU - Zhang, Ping

    AU - Cripps, Allan W.

    AU - West, Nicholas P.

    PY - 2018

    Y1 - 2018

    N2 - Upper respiratory symptoms remain the most common illness in athletes. Upper respiratory symptoms during heavy training and competition may impair performance. Preventing illness is the primary reason for the use of supplements, such as probiotics and prebiotics, for maintaining or promoting gut health and immune function. While exercise-induced perturbations in the immune system may increase susceptibility to illness and infection, growing evidence indicates that upper respiratory symptoms are related to a breakdown in the homeostatic regulation of the mucosal immune system of the airways. Balancing protection of the respiratory tract with normal physiological functioning requires dynamic orchestration between a wide array of immune parameters. The intestinal microbiota regulates extra-intestinal immunity via the common mucosal immune system and new evidence implicates the microbiota of the nose, mouth and respiratory tract in upper respiratory symptoms. Omics’ approaches now facilitate comprehensive profiling at the molecular and proteomic levels to reveal new pathways and molecules of immune regulation. New targets may provide for personalised nutritional and training interventions to maintain athlete health.

    AB - Upper respiratory symptoms remain the most common illness in athletes. Upper respiratory symptoms during heavy training and competition may impair performance. Preventing illness is the primary reason for the use of supplements, such as probiotics and prebiotics, for maintaining or promoting gut health and immune function. While exercise-induced perturbations in the immune system may increase susceptibility to illness and infection, growing evidence indicates that upper respiratory symptoms are related to a breakdown in the homeostatic regulation of the mucosal immune system of the airways. Balancing protection of the respiratory tract with normal physiological functioning requires dynamic orchestration between a wide array of immune parameters. The intestinal microbiota regulates extra-intestinal immunity via the common mucosal immune system and new evidence implicates the microbiota of the nose, mouth and respiratory tract in upper respiratory symptoms. Omics’ approaches now facilitate comprehensive profiling at the molecular and proteomic levels to reveal new pathways and molecules of immune regulation. New targets may provide for personalised nutritional and training interventions to maintain athlete health.

    UR - http://www.scopus.com/inward/record.url?scp=85040865502&partnerID=8YFLogxK

    U2 - 10.1007/s40279-017-0846-4

    DO - 10.1007/s40279-017-0846-4

    M3 - Article

    VL - 48

    SP - 65

    EP - 77

    JO - Sports Medicine

    JF - Sports Medicine

    SN - 0112-1642

    ER -