Urine adulteration: Can bleach be used to mask MDMA use?

Annie Q N Pham, Tamsin KELLY, Shanlin Fu

Research output: Contribution to journalArticle

4 Citations (Scopus)
2 Downloads (Pure)

Abstract

Concerns regarding specimen integrity have long been a major issue of urine drug testing due to acts of urine adulteration. At a high concentration, in vitro urine adulteration using sodium hypochlorite (bleach) produced false-negative results for 3,4-methylenedioxymethamphetamine (MDMA) in CEDIA® immunoassay screening with strong negative readings. However, these strong negative readings may act as a warning sign for further investigation of the sample where the detection of a unique marker in the form of N-chloroMDMA will suggest urine adulteration via bleach. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified N-chloroMDMA is a major product formed between hypochlorite and MDMA in urine. N-ChloroMDMA was found stable at 4 °C for at least 10 h, but decomposed over time at room temperature (20 °C) with MDMA being identified as one of its main decomposition products
Original languageEnglish
Pages (from-to)3948-3955
Number of pages8
JournalAnalytical Methods
Volume5
Issue number16
DOIs
Publication statusPublished - 2013

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N-Methyl-3,4-methylenedioxyamphetamine
Liquid chromatography
Mass spectrometry
Masks
Screening
Sodium
Decomposition
Testing
Hypochlorous Acid
Sodium Hypochlorite
Temperature
Pharmaceutical Preparations

Cite this

Pham, Annie Q N ; KELLY, Tamsin ; Fu, Shanlin. / Urine adulteration: Can bleach be used to mask MDMA use?. In: Analytical Methods. 2013 ; Vol. 5, No. 16. pp. 3948-3955.
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Urine adulteration: Can bleach be used to mask MDMA use? / Pham, Annie Q N; KELLY, Tamsin; Fu, Shanlin.

In: Analytical Methods, Vol. 5, No. 16, 2013, p. 3948-3955.

Research output: Contribution to journalArticle

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T1 - Urine adulteration: Can bleach be used to mask MDMA use?

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AU - Fu, Shanlin

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