Abstract
Concerns regarding specimen integrity have long been a major issue of urine drug testing due to acts of urine adulteration. At a high concentration, in vitro urine adulteration using sodium hypochlorite (bleach) produced false-negative results for 3,4-methylenedioxymethamphetamine (MDMA) in CEDIA® immunoassay screening with strong negative readings. However, these strong negative readings may act as a warning sign for further investigation of the sample where the detection of a unique marker in the form of N-chloroMDMA will suggest urine adulteration via bleach. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified N-chloroMDMA is a major product formed between hypochlorite and MDMA in urine. N-ChloroMDMA was found stable at 4 °C for at least 10 h, but decomposed over time at room temperature (20 °C) with MDMA being identified as one of its main decomposition products
| Original language | English |
|---|---|
| Pages (from-to) | 3948-3955 |
| Number of pages | 8 |
| Journal | Analytical Methods |
| Volume | 5 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 2013 |
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Pham, A. Q. N., KELLY, T., & Fu, S. (2013). Urine adulteration: Can bleach be used to mask MDMA use? Analytical Methods, 5(16), 3948-3955. https://doi.org/10.1039/c3ay40543e