Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 3948-3955 |
| Number of pages | 8 |
| Journal | Analytical Methods |
| Volume | 5 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 2013 |
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Urine adulteration: Can bleach be used to mask MDMA use? / Pham, Annie Q N; KELLY, Tamsin; Fu, Shanlin.
In: Analytical Methods, Vol. 5, No. 16, 2013, p. 3948-3955.Research output: Contribution to journal › Article
TY - JOUR
T1 - Urine adulteration: Can bleach be used to mask MDMA use?
AU - Pham, Annie Q N
AU - KELLY, Tamsin
AU - Fu, Shanlin
PY - 2013
Y1 - 2013
N2 - Concerns regarding specimen integrity have long been a major issue of urine drug testing due to acts of urine adulteration. At a high concentration, in vitro urine adulteration using sodium hypochlorite (bleach) produced false-negative results for 3,4-methylenedioxymethamphetamine (MDMA) in CEDIA® immunoassay screening with strong negative readings. However, these strong negative readings may act as a warning sign for further investigation of the sample where the detection of a unique marker in the form of N-chloroMDMA will suggest urine adulteration via bleach. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified N-chloroMDMA is a major product formed between hypochlorite and MDMA in urine. N-ChloroMDMA was found stable at 4 °C for at least 10 h, but decomposed over time at room temperature (20 °C) with MDMA being identified as one of its main decomposition products
AB - Concerns regarding specimen integrity have long been a major issue of urine drug testing due to acts of urine adulteration. At a high concentration, in vitro urine adulteration using sodium hypochlorite (bleach) produced false-negative results for 3,4-methylenedioxymethamphetamine (MDMA) in CEDIA® immunoassay screening with strong negative readings. However, these strong negative readings may act as a warning sign for further investigation of the sample where the detection of a unique marker in the form of N-chloroMDMA will suggest urine adulteration via bleach. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified N-chloroMDMA is a major product formed between hypochlorite and MDMA in urine. N-ChloroMDMA was found stable at 4 °C for at least 10 h, but decomposed over time at room temperature (20 °C) with MDMA being identified as one of its main decomposition products
KW - 3
KW - 4-methylenedioxymethlamphetamine
KW - urine adulteration
U2 - 10.1039/c3ay40543e
DO - 10.1039/c3ay40543e
M3 - Article
VL - 5
SP - 3948
EP - 3955
JO - Analytical Methods
JF - Analytical Methods
SN - 1759-9660
IS - 16
ER -