### Abstract

Background: Indicators of cardiometabolic risk typically include non-clinical factors (e.g., smoking). While the incorporation of non-clinical factors can improve absolute risk prediction, it is impossible to study the contribution of non-clinical factors when they are both predictors and part of the outcome measure. Metabolic syndrome, incorporating only clinical measures, seems a solution yet provides no information on risk severity. The aims of this study were: 1) to construct two continuous clinical indices of cardiometabolic risk (cCICRs), and assess their accuracy in predicting 10-year incident cardiovascular disease and/or type 2 diabetes; and 2) to compare the predictive accuracies of these cCICRs with existing risk indicators that incorporate non-clinical factors (Framingham Risk Scores).Methods: Data from a population-based biomedical cohort (n = 4056) were used to construct two cCICRs from waist circumference, mean arteriole pressure, fasting glucose, triglycerides and high density lipoprotein: 1) the mean of standardised risk factors (cCICR-Z); and 2) the weighted mean of the two first principal components from principal component analysis (cCICR-PCA). The predictive accuracies of the two cCICRs and the Framingham Risk Scores were assessed and compared using ROC curves.Results: Both cCICRs demonstrated moderate accuracy (AUCs 0.72 – 0.76) in predicting incident cardiovascular disease and/or type 2 diabetes, among men and women. There were no significant differences between the predictive accuracies of the cCICRs and the Framingham Risk Scores.Conclusions: cCICRs may be useful in research investigating associations between non-clinical factors and health by providing suitable alternatives to current risk indicators which include non-clinical factors.

Original language | English |
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Article number | 27 |

Pages (from-to) | 1-9 |

Number of pages | 9 |

Journal | BMC Cardiovascular Disorders |

Volume | 14 |

Issue number | 27 |

DOIs | |

Publication status | Published - 2014 |

Externally published | Yes |

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## Cite this

CARROLL, S., Paquet, C., Howard, N., Adams, R., Taylor, A., & DANIEL, M. (2014). Validation of continuous clinical indices of cardiometabolic risk in a cohort of Australian adults.

*BMC Cardiovascular Disorders*,*14*(27), 1-9. [27]. https://doi.org/10.1186/1471-2261-14-27