Abstract
| Original language | English |
|---|---|
| Article number | 27 |
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | BMC Cardiovascular Disorders |
| Volume | 14 |
| Issue number | 27 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
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Validation of continuous clinical indices of cardiometabolic risk in a cohort of Australian adults. / CARROLL, Suzanne; Paquet, Catherine; Howard, Natasha; Adams, Robert; Taylor, Anne; DANIEL, Mark.
In: BMC Cardiovascular Disorders, Vol. 14, No. 27, 27, 2014, p. 1-9.Research output: Contribution to journal › Article
TY - JOUR
T1 - Validation of continuous clinical indices of cardiometabolic risk in a cohort of Australian adults
AU - CARROLL, Suzanne
AU - Paquet, Catherine
AU - Howard, Natasha
AU - Adams, Robert
AU - Taylor, Anne
AU - DANIEL, Mark
PY - 2014
Y1 - 2014
N2 - Background: Indicators of cardiometabolic risk typically include non-clinical factors (e.g., smoking). While the incorporation of non-clinical factors can improve absolute risk prediction, it is impossible to study the contribution of non-clinical factors when they are both predictors and part of the outcome measure. Metabolic syndrome, incorporating only clinical measures, seems a solution yet provides no information on risk severity. The aims of this study were: 1) to construct two continuous clinical indices of cardiometabolic risk (cCICRs), and assess their accuracy in predicting 10-year incident cardiovascular disease and/or type 2 diabetes; and 2) to compare the predictive accuracies of these cCICRs with existing risk indicators that incorporate non-clinical factors (Framingham Risk Scores).Methods: Data from a population-based biomedical cohort (n = 4056) were used to construct two cCICRs from waist circumference, mean arteriole pressure, fasting glucose, triglycerides and high density lipoprotein: 1) the mean of standardised risk factors (cCICR-Z); and 2) the weighted mean of the two first principal components from principal component analysis (cCICR-PCA). The predictive accuracies of the two cCICRs and the Framingham Risk Scores were assessed and compared using ROC curves.Results: Both cCICRs demonstrated moderate accuracy (AUCs 0.72 – 0.76) in predicting incident cardiovascular disease and/or type 2 diabetes, among men and women. There were no significant differences between the predictive accuracies of the cCICRs and the Framingham Risk Scores.Conclusions: cCICRs may be useful in research investigating associations between non-clinical factors and health by providing suitable alternatives to current risk indicators which include non-clinical factors.
AB - Background: Indicators of cardiometabolic risk typically include non-clinical factors (e.g., smoking). While the incorporation of non-clinical factors can improve absolute risk prediction, it is impossible to study the contribution of non-clinical factors when they are both predictors and part of the outcome measure. Metabolic syndrome, incorporating only clinical measures, seems a solution yet provides no information on risk severity. The aims of this study were: 1) to construct two continuous clinical indices of cardiometabolic risk (cCICRs), and assess their accuracy in predicting 10-year incident cardiovascular disease and/or type 2 diabetes; and 2) to compare the predictive accuracies of these cCICRs with existing risk indicators that incorporate non-clinical factors (Framingham Risk Scores).Methods: Data from a population-based biomedical cohort (n = 4056) were used to construct two cCICRs from waist circumference, mean arteriole pressure, fasting glucose, triglycerides and high density lipoprotein: 1) the mean of standardised risk factors (cCICR-Z); and 2) the weighted mean of the two first principal components from principal component analysis (cCICR-PCA). The predictive accuracies of the two cCICRs and the Framingham Risk Scores were assessed and compared using ROC curves.Results: Both cCICRs demonstrated moderate accuracy (AUCs 0.72 – 0.76) in predicting incident cardiovascular disease and/or type 2 diabetes, among men and women. There were no significant differences between the predictive accuracies of the cCICRs and the Framingham Risk Scores.Conclusions: cCICRs may be useful in research investigating associations between non-clinical factors and health by providing suitable alternatives to current risk indicators which include non-clinical factors.
KW - AUC
KW - Cardiometabolic
KW - Cardiovascular disease
KW - ROC
KW - Risk scores
KW - Type 2 diabetes
KW - Validation
UR - http://www.scopus.com/inward/record.url?scp=84897574879&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/validation-continuous-clinical-indices-cardiometabolic-risk-cohort-australian-adults
U2 - 10.1186/1471-2261-14-27
DO - 10.1186/1471-2261-14-27
M3 - Article
VL - 14
SP - 1
EP - 9
JO - BMC Cardiovascular Disorders
JF - BMC Cardiovascular Disorders
SN - 1471-2261
IS - 27
M1 - 27
ER -