Validity of arterialised-venous PCO2, pH and bicarbonate in obesity hypoventilation syndrome

Carly A. Hollier, Lyndal J. Maxwell, Alison R. Harmer, Collette Menadue, Amanda J. Piper, Deborah A. Black, Grant WILLSON, Jennifer A. Alison

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Abstract

This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide (PCO2), pH and bicarbonate (HCO3−) in people with obesity hypoventilation syndrome (OHS). AVBGs were obtained from an upper limb vein, after heating the skin at 42–46 °C. Arterial blood gas (ABG) and AVBG samples were taken simultaneously and compared using Bland Altman analysis. Between-group differences were assessed with independent t-tests or Mann–Whitney U tests. Forty-two viable paired samples were analysed, including 27 paired samples from 15 OHS participants, and 15 paired samples from 16 controls. AVBG–ABG agreement was not different between groups, or between dorsal hand, forearm and antecubital AVBG sampling sites, and was clinically acceptable for PCO2: mean difference (MD) 0.4 mmHg (0.9%), limits of agreement (LOA) −2.7–3.6 mmHg (±6.6%); pH: MD −0.008 (−0.1%), LOA −0.023–0.008 (±0.2%); and HCO3−: MD −0.3 mmol L−1 (−1.0%), LOA −1.8–1.2 mmol L−1 (±5.3%). AVBG provides valid measures of PCO2, pH, and HCO3− in OHS
Original languageEnglish
Pages (from-to)165-171
Number of pages7
JournalRespiratory Physiology and Neurobiology
Volume188
Issue number2
DOIs
Publication statusPublished - 2013

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Obesity Hypoventilation Syndrome
Bicarbonates
Gases
Forearm
Carbon Dioxide
Upper Extremity
Heating
Veins
Hand
Prospective Studies
Skin

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Hollier, C. A., Maxwell, L. J., Harmer, A. R., Menadue, C., Piper, A. J., Black, D. A., ... Alison, J. A. (2013). Validity of arterialised-venous PCO2, pH and bicarbonate in obesity hypoventilation syndrome. Respiratory Physiology and Neurobiology, 188(2), 165-171. https://doi.org/10.1016/j.resp.2013.05.031
Hollier, Carly A. ; Maxwell, Lyndal J. ; Harmer, Alison R. ; Menadue, Collette ; Piper, Amanda J. ; Black, Deborah A. ; WILLSON, Grant ; Alison, Jennifer A. / Validity of arterialised-venous PCO2, pH and bicarbonate in obesity hypoventilation syndrome. In: Respiratory Physiology and Neurobiology. 2013 ; Vol. 188, No. 2. pp. 165-171.
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abstract = "This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide (PCO2), pH and bicarbonate (HCO3−) in people with obesity hypoventilation syndrome (OHS). AVBGs were obtained from an upper limb vein, after heating the skin at 42–46 °C. Arterial blood gas (ABG) and AVBG samples were taken simultaneously and compared using Bland Altman analysis. Between-group differences were assessed with independent t-tests or Mann–Whitney U tests. Forty-two viable paired samples were analysed, including 27 paired samples from 15 OHS participants, and 15 paired samples from 16 controls. AVBG–ABG agreement was not different between groups, or between dorsal hand, forearm and antecubital AVBG sampling sites, and was clinically acceptable for PCO2: mean difference (MD) 0.4 mmHg (0.9{\%}), limits of agreement (LOA) −2.7–3.6 mmHg (±6.6{\%}); pH: MD −0.008 (−0.1{\%}), LOA −0.023–0.008 (±0.2{\%}); and HCO3−: MD −0.3 mmol L−1 (−1.0{\%}), LOA −1.8–1.2 mmol L−1 (±5.3{\%}). AVBG provides valid measures of PCO2, pH, and HCO3− in OHS",
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Hollier, CA, Maxwell, LJ, Harmer, AR, Menadue, C, Piper, AJ, Black, DA, WILLSON, G & Alison, JA 2013, 'Validity of arterialised-venous PCO2, pH and bicarbonate in obesity hypoventilation syndrome', Respiratory Physiology and Neurobiology, vol. 188, no. 2, pp. 165-171. https://doi.org/10.1016/j.resp.2013.05.031

Validity of arterialised-venous PCO2, pH and bicarbonate in obesity hypoventilation syndrome. / Hollier, Carly A.; Maxwell, Lyndal J.; Harmer, Alison R.; Menadue, Collette; Piper, Amanda J.; Black, Deborah A.; WILLSON, Grant; Alison, Jennifer A.

In: Respiratory Physiology and Neurobiology, Vol. 188, No. 2, 2013, p. 165-171.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Validity of arterialised-venous PCO2, pH and bicarbonate in obesity hypoventilation syndrome

AU - Hollier, Carly A.

AU - Maxwell, Lyndal J.

AU - Harmer, Alison R.

AU - Menadue, Collette

AU - Piper, Amanda J.

AU - Black, Deborah A.

AU - WILLSON, Grant

AU - Alison, Jennifer A.

PY - 2013

Y1 - 2013

N2 - This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide (PCO2), pH and bicarbonate (HCO3−) in people with obesity hypoventilation syndrome (OHS). AVBGs were obtained from an upper limb vein, after heating the skin at 42–46 °C. Arterial blood gas (ABG) and AVBG samples were taken simultaneously and compared using Bland Altman analysis. Between-group differences were assessed with independent t-tests or Mann–Whitney U tests. Forty-two viable paired samples were analysed, including 27 paired samples from 15 OHS participants, and 15 paired samples from 16 controls. AVBG–ABG agreement was not different between groups, or between dorsal hand, forearm and antecubital AVBG sampling sites, and was clinically acceptable for PCO2: mean difference (MD) 0.4 mmHg (0.9%), limits of agreement (LOA) −2.7–3.6 mmHg (±6.6%); pH: MD −0.008 (−0.1%), LOA −0.023–0.008 (±0.2%); and HCO3−: MD −0.3 mmol L−1 (−1.0%), LOA −1.8–1.2 mmol L−1 (±5.3%). AVBG provides valid measures of PCO2, pH, and HCO3− in OHS

AB - This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide (PCO2), pH and bicarbonate (HCO3−) in people with obesity hypoventilation syndrome (OHS). AVBGs were obtained from an upper limb vein, after heating the skin at 42–46 °C. Arterial blood gas (ABG) and AVBG samples were taken simultaneously and compared using Bland Altman analysis. Between-group differences were assessed with independent t-tests or Mann–Whitney U tests. Forty-two viable paired samples were analysed, including 27 paired samples from 15 OHS participants, and 15 paired samples from 16 controls. AVBG–ABG agreement was not different between groups, or between dorsal hand, forearm and antecubital AVBG sampling sites, and was clinically acceptable for PCO2: mean difference (MD) 0.4 mmHg (0.9%), limits of agreement (LOA) −2.7–3.6 mmHg (±6.6%); pH: MD −0.008 (−0.1%), LOA −0.023–0.008 (±0.2%); and HCO3−: MD −0.3 mmol L−1 (−1.0%), LOA −1.8–1.2 mmol L−1 (±5.3%). AVBG provides valid measures of PCO2, pH, and HCO3− in OHS

KW - Arterialised-venous

KW - Blood gas

KW - Obesity

KW - Obesity hypoventilation syndrome

KW - Validation

U2 - 10.1016/j.resp.2013.05.031

DO - 10.1016/j.resp.2013.05.031

M3 - Article

VL - 188

SP - 165

EP - 171

JO - Respiration Physiology

JF - Respiration Physiology

SN - 1569-9048

IS - 2

ER -