Variation in the pharmacokinetics of glucosamine in healthy individuals

Chhavi Asthana, Gregory M. Peterson, Madhur D. Shastri, Rahul P. Patel

Research output: Contribution to journalShort Survey/Scientific Reportpeer-review

Abstract

Objectives
Clinical trial data for the efficacy of glucosamine in OA are conflicting. Reportedly, Rotta-manufactured glucosamine products are more likely to be effective, and a possible explanation is greater bioavailability than other brands. Specifically, the aim was to compare the steady-state pharmacokinetics of Rotta- and non-Rotta-manufactured glucosamine products in healthy volunteers and examine the interindividual variability.

Methods
In a crossover design, healthy adult participants ingested 1500 mg/day of a Rotta (DONA powder sachets; imported by Mylan Health, Carole Park, QLD, Australia) and a non-Rotta (glucosamine sulphate 1500 mg one-a-day tablet; Blackmores, Warriewood, NSW, Australia) glucosamine product/brand individually for 6 days. Blood samples were collected immediately before and for 12 h after the ingestion of the last dose of each brand and analysed to determine plasma levels of glucosamine. The pharmacokinetic parameters at steady state [including the minimum (Css min) and maximum (Css max) plasma concentration of glucosamine, time to reach Css max post-dosing (Tss max) and area under the plasma concentration vs time curve (AUCss 0–12)] for each brand were calculated and statistically compared.

Results
Fourteen participants [mean age 35.5 years (S.D. 8.8)] were recruited (64.2% males). No significant differences were observed in the pharmacokinetic parameters between the two brands. However, for both brands, the coefficient of variation for Css min, Tss max and AUCss 0–12 exceeded 20%, indicating considerable differences in the parameters between participants. No significant association of the pharmacokinetic parameters was observed with various dosing- and participant-related variables.

Conclusion
Substantial interindividual differences in the absorption and elimination of glucosamine could be a cause of variable clinical outcomes in OA.
Original languageEnglish
Pages (from-to)1205-1209
Number of pages5
JournalRheumatology
Volume60
Issue number3
DOIs
Publication statusPublished - 1 Mar 2021

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