TY - JOUR
T1 - Visceral adiposity index outperforms common anthropometric indices in predicting 10-year diabetes risk
T2 - Results from the ATTICA study
AU - the ATTICA Study group
AU - Koloverou, Efi
AU - Panagiotakos, Demosthenes B.
AU - Kyrou, Ioannis
AU - Stefanadis, Christodoulos
AU - Chrysohoou, Christina
AU - Georgousopoulou, Ekavi N.
AU - Skoumas, Ioannis
AU - Tousoulis, Dimitrios
AU - Pitsavos, Christos
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Background: Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common anthropometric indices. Methods: In 2001 to 2002, the ATTICA study (Greece) recruited a random sample of 1514 and 1528 CVD-free men (18-87 years old) and women (18-89 years old), respectively. Sociodemographic, lifestyle, clinical, and biochemical characteristics of participants were measured at baseline, and the 10-year follow-up was performed during 2011 to 2012. After excluding participants with diabetes at baseline and participants without complete follow-up information regarding diabetes status and/or baseline VAI values, the working sample consisted of 1049 participants. In this sample, the predictive value of baseline VAI value was studied in relation to 10-year diabetes incidence. Results: One hundred thirty-three incident cases of diabetes were documented (10-year incidence: 12.7%). In the fully adjusted model, VAI significantly increased diabetes risk by 22% (OR per 1-unit increase =1.22; 95%CI, 1.09-1.37). Markers of oxidative stress and inflammation were found to, at least partly, mediate this relationship. Also, a moderating effect of menstruation status was revealed among women. VAI showed the highest predictive ability and contributed the most, along with waist-to-height ratio, to the correct classification of participants who developed diabetes. Conclusions: The present findings suggest that VAI may be a useful index for predicting long-term diabetes development and may exhibit better predictive ability to commonly used anthropometric indices.
AB - Background: Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common anthropometric indices. Methods: In 2001 to 2002, the ATTICA study (Greece) recruited a random sample of 1514 and 1528 CVD-free men (18-87 years old) and women (18-89 years old), respectively. Sociodemographic, lifestyle, clinical, and biochemical characteristics of participants were measured at baseline, and the 10-year follow-up was performed during 2011 to 2012. After excluding participants with diabetes at baseline and participants without complete follow-up information regarding diabetes status and/or baseline VAI values, the working sample consisted of 1049 participants. In this sample, the predictive value of baseline VAI value was studied in relation to 10-year diabetes incidence. Results: One hundred thirty-three incident cases of diabetes were documented (10-year incidence: 12.7%). In the fully adjusted model, VAI significantly increased diabetes risk by 22% (OR per 1-unit increase =1.22; 95%CI, 1.09-1.37). Markers of oxidative stress and inflammation were found to, at least partly, mediate this relationship. Also, a moderating effect of menstruation status was revealed among women. VAI showed the highest predictive ability and contributed the most, along with waist-to-height ratio, to the correct classification of participants who developed diabetes. Conclusions: The present findings suggest that VAI may be a useful index for predicting long-term diabetes development and may exhibit better predictive ability to commonly used anthropometric indices.
KW - anthropometric indices
KW - prognostic markers
KW - type 2 diabetes
KW - VAI
KW - visceral adiposity index
UR - http://www.scopus.com/inward/record.url?scp=85064820618&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/visceral-adiposity-index-outperforms-common-anthropometric-indices-predicting-10year-diabetes-risk-r-1
U2 - 10.1002/dmrr.3161
DO - 10.1002/dmrr.3161
M3 - Article
C2 - 30912290
AN - SCOPUS:85064820618
SN - 1520-7552
VL - 35
SP - 1
EP - 9
JO - Diabetes/Metabolism Research and Reviews
JF - Diabetes/Metabolism Research and Reviews
IS - 6
M1 - e3161
ER -