Visual function and correlation with retinal structure in sports-related mild traumatic brain injury (mTBI)

Faran SABETI, Corinne F. Carle, Rachel Jaros, Emilie Rohan, Christian J. Lueck, Ted Maddess

Research output: Contribution to conference (non-published works)Paper

Abstract

AIMS: To investigate the effect of mild traumatic brain injury (mTBI) on retinal thickness as measured by optical coherence tomography (OCT), and on visual function as assessed by multifocal pupillary objective perimetry (mfPOP). METHODS: Thirty-seven male athletes with a history of acute concussion occurring 4 - 36 days previously (aged 21.6 ± 2.1 years, mean ± SD), eleven athletes with a history of head trauma 39 - 666 days previously (20.9 ± 2.0 years), and twelve athletes with no history of head trauma (22.5 ± 2.7 years) were compared to eighteen non-athlete controls (22.1 ± 1.9 years). Pupillary response amplitudes and delays were measured to 44 multifocal, dichoptic, regional stimulus presentations extending out to ±30° from the fovea. Full retinal thickness was measured with OCT in the nine zones of the Early Treatment Diabetic Retinopathy study (ETDRS) and this was correlated with the average pupillary response to stimulation in each zone. RESULTS: On average, athletes who suffered acute mTBI showed a significant reduction in response amplitude (-2.44 ± 0.48 dB, P < 0.0001). Response amplitudes of athletes with chronic mTBI were reduced relative to controls but this did not reach significance (-0.58 ± 0.48 dB, P =0.23). Local retinal thickness and pupillary response delays showed a significant negative correlation for all ETDRS retinal regions in athletes with acute mTBI (P < 0.05) but not in other groups. CONCLUSION: Response amplitudes were more informative than delay. A significant effect on pupillary response amplitudes were seen in the acute mTBI athletes whereas the chronic mTBI athletes demonstrated significant delay. A significant negative association between response delay and retinal thickness was found in acute mTBI. Pupillary response dynamics, particularly in conjunction with structural retinal changes, may be a potential biomarker of mild head trauma.
Original languageEnglish
Publication statusPublished - 13 Sep 2018
EventNeuro-Ophthalmology Society of Australia annual conference - Melbourne, Melbourne, Australia
Duration: 13 Sep 201814 Sep 2018

Conference

ConferenceNeuro-Ophthalmology Society of Australia annual conference
CountryAustralia
CityMelbourne
Period13/09/1814/09/18

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Brain Concussion
Athletes
Sports
Craniocerebral Trauma
Optical Coherence Tomography
Diabetic Retinopathy
Visual Field Tests
Biomarkers

Cite this

SABETI, F., Carle, C. F., Jaros, R., Rohan, E., Lueck, C. J., & Maddess, T. (2018). Visual function and correlation with retinal structure in sports-related mild traumatic brain injury (mTBI). Paper presented at Neuro-Ophthalmology Society of Australia annual conference, Melbourne, Australia.
SABETI, Faran ; Carle, Corinne F. ; Jaros, Rachel ; Rohan, Emilie ; Lueck, Christian J. ; Maddess, Ted. / Visual function and correlation with retinal structure in sports-related mild traumatic brain injury (mTBI). Paper presented at Neuro-Ophthalmology Society of Australia annual conference, Melbourne, Australia.
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abstract = "AIMS: To investigate the effect of mild traumatic brain injury (mTBI) on retinal thickness as measured by optical coherence tomography (OCT), and on visual function as assessed by multifocal pupillary objective perimetry (mfPOP). METHODS: Thirty-seven male athletes with a history of acute concussion occurring 4 - 36 days previously (aged 21.6 ± 2.1 years, mean ± SD), eleven athletes with a history of head trauma 39 - 666 days previously (20.9 ± 2.0 years), and twelve athletes with no history of head trauma (22.5 ± 2.7 years) were compared to eighteen non-athlete controls (22.1 ± 1.9 years). Pupillary response amplitudes and delays were measured to 44 multifocal, dichoptic, regional stimulus presentations extending out to ±30° from the fovea. Full retinal thickness was measured with OCT in the nine zones of the Early Treatment Diabetic Retinopathy study (ETDRS) and this was correlated with the average pupillary response to stimulation in each zone. RESULTS: On average, athletes who suffered acute mTBI showed a significant reduction in response amplitude (-2.44 ± 0.48 dB, P < 0.0001). Response amplitudes of athletes with chronic mTBI were reduced relative to controls but this did not reach significance (-0.58 ± 0.48 dB, P =0.23). Local retinal thickness and pupillary response delays showed a significant negative correlation for all ETDRS retinal regions in athletes with acute mTBI (P < 0.05) but not in other groups. CONCLUSION: Response amplitudes were more informative than delay. A significant effect on pupillary response amplitudes were seen in the acute mTBI athletes whereas the chronic mTBI athletes demonstrated significant delay. A significant negative association between response delay and retinal thickness was found in acute mTBI. Pupillary response dynamics, particularly in conjunction with structural retinal changes, may be a potential biomarker of mild head trauma.",
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SABETI, F, Carle, CF, Jaros, R, Rohan, E, Lueck, CJ & Maddess, T 2018, 'Visual function and correlation with retinal structure in sports-related mild traumatic brain injury (mTBI)' Paper presented at Neuro-Ophthalmology Society of Australia annual conference, Melbourne, Australia, 13/09/18 - 14/09/18, .

Visual function and correlation with retinal structure in sports-related mild traumatic brain injury (mTBI). / SABETI, Faran; Carle, Corinne F.; Jaros, Rachel; Rohan, Emilie; Lueck, Christian J.; Maddess, Ted.

2018. Paper presented at Neuro-Ophthalmology Society of Australia annual conference, Melbourne, Australia.

Research output: Contribution to conference (non-published works)Paper

TY - CONF

T1 - Visual function and correlation with retinal structure in sports-related mild traumatic brain injury (mTBI)

AU - SABETI, Faran

AU - Carle, Corinne F.

AU - Jaros, Rachel

AU - Rohan, Emilie

AU - Lueck, Christian J.

AU - Maddess, Ted

PY - 2018/9/13

Y1 - 2018/9/13

N2 - AIMS: To investigate the effect of mild traumatic brain injury (mTBI) on retinal thickness as measured by optical coherence tomography (OCT), and on visual function as assessed by multifocal pupillary objective perimetry (mfPOP). METHODS: Thirty-seven male athletes with a history of acute concussion occurring 4 - 36 days previously (aged 21.6 ± 2.1 years, mean ± SD), eleven athletes with a history of head trauma 39 - 666 days previously (20.9 ± 2.0 years), and twelve athletes with no history of head trauma (22.5 ± 2.7 years) were compared to eighteen non-athlete controls (22.1 ± 1.9 years). Pupillary response amplitudes and delays were measured to 44 multifocal, dichoptic, regional stimulus presentations extending out to ±30° from the fovea. Full retinal thickness was measured with OCT in the nine zones of the Early Treatment Diabetic Retinopathy study (ETDRS) and this was correlated with the average pupillary response to stimulation in each zone. RESULTS: On average, athletes who suffered acute mTBI showed a significant reduction in response amplitude (-2.44 ± 0.48 dB, P < 0.0001). Response amplitudes of athletes with chronic mTBI were reduced relative to controls but this did not reach significance (-0.58 ± 0.48 dB, P =0.23). Local retinal thickness and pupillary response delays showed a significant negative correlation for all ETDRS retinal regions in athletes with acute mTBI (P < 0.05) but not in other groups. CONCLUSION: Response amplitudes were more informative than delay. A significant effect on pupillary response amplitudes were seen in the acute mTBI athletes whereas the chronic mTBI athletes demonstrated significant delay. A significant negative association between response delay and retinal thickness was found in acute mTBI. Pupillary response dynamics, particularly in conjunction with structural retinal changes, may be a potential biomarker of mild head trauma.

AB - AIMS: To investigate the effect of mild traumatic brain injury (mTBI) on retinal thickness as measured by optical coherence tomography (OCT), and on visual function as assessed by multifocal pupillary objective perimetry (mfPOP). METHODS: Thirty-seven male athletes with a history of acute concussion occurring 4 - 36 days previously (aged 21.6 ± 2.1 years, mean ± SD), eleven athletes with a history of head trauma 39 - 666 days previously (20.9 ± 2.0 years), and twelve athletes with no history of head trauma (22.5 ± 2.7 years) were compared to eighteen non-athlete controls (22.1 ± 1.9 years). Pupillary response amplitudes and delays were measured to 44 multifocal, dichoptic, regional stimulus presentations extending out to ±30° from the fovea. Full retinal thickness was measured with OCT in the nine zones of the Early Treatment Diabetic Retinopathy study (ETDRS) and this was correlated with the average pupillary response to stimulation in each zone. RESULTS: On average, athletes who suffered acute mTBI showed a significant reduction in response amplitude (-2.44 ± 0.48 dB, P < 0.0001). Response amplitudes of athletes with chronic mTBI were reduced relative to controls but this did not reach significance (-0.58 ± 0.48 dB, P =0.23). Local retinal thickness and pupillary response delays showed a significant negative correlation for all ETDRS retinal regions in athletes with acute mTBI (P < 0.05) but not in other groups. CONCLUSION: Response amplitudes were more informative than delay. A significant effect on pupillary response amplitudes were seen in the acute mTBI athletes whereas the chronic mTBI athletes demonstrated significant delay. A significant negative association between response delay and retinal thickness was found in acute mTBI. Pupillary response dynamics, particularly in conjunction with structural retinal changes, may be a potential biomarker of mild head trauma.

M3 - Paper

ER -

SABETI F, Carle CF, Jaros R, Rohan E, Lueck CJ, Maddess T. Visual function and correlation with retinal structure in sports-related mild traumatic brain injury (mTBI). 2018. Paper presented at Neuro-Ophthalmology Society of Australia annual conference, Melbourne, Australia.