TY - JOUR
T1 - Why don't serum Vitamin D concentrations associate with BMD by DXA?
T2 - A case of being 'bound' to the wrong assay? Implications for Vitamin D screening
AU - Allison, Richard J.
AU - Farooq, Abdulaziz
AU - Cherif, Anissa
AU - Hamilton, Bruce
AU - Close, Graeme L.
AU - Wilson, Mathew G.
N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2018/4
Y1 - 2018/4
N2 - Background: The association between bone mineral density (BMD) and serum25-hydroxyvitamin D (25(OH)D) concentration is weak, particularly in certain races (eg, BlackAfrican vs Caucasian) and in athletic populations. We aimed to examine if bioavailable vitamin D rather than serum 25(OH)D was related to markers of bone health within a racially diverse athletic population. Methods: In 604 male athletes (Arab (n=327), Asian (n=48), Black (n=108), Caucasian (n=53) and Hispanic (n=68)), we measured total 25(OH)D, vitamin D-binding protein and BMD by DXA. Bioavailable vitamin D was calculated using the free hormone hypothesis. Results: From 604 athletes, 21.5% (n=130) demonstrated severe 25(OH)D deficiency, 37.1% (n=224) deficiency, 26% (n=157) insufficiency and 15.4% (n=93) sufficiency. Serum 25(OH)D concentrations were not associated with BMD at any site. After adjusting for age and race, bioavailable vitamin D was associated with BMD (spine, neck and hip). Mean serum vitamin D binding protein concentrations were not associated with 25(OH)D concentrations (p=0.392). Conclusion: Regardless of age or race, bioavailable vitamin D and not serum 25(OH)D was associated with BMD in a racially diverse athletic population. If vitamin D screening is warranted, clinicians should use appropriate assays to calculate vitamin D binding protein and bioavailable vitamin D levels concentrations than serum 25(OH)D. In turn, prophylactic vitamin D supplementation to â 'correct' insufficient athletes should not be based on serum 25(OH)D measures.
AB - Background: The association between bone mineral density (BMD) and serum25-hydroxyvitamin D (25(OH)D) concentration is weak, particularly in certain races (eg, BlackAfrican vs Caucasian) and in athletic populations. We aimed to examine if bioavailable vitamin D rather than serum 25(OH)D was related to markers of bone health within a racially diverse athletic population. Methods: In 604 male athletes (Arab (n=327), Asian (n=48), Black (n=108), Caucasian (n=53) and Hispanic (n=68)), we measured total 25(OH)D, vitamin D-binding protein and BMD by DXA. Bioavailable vitamin D was calculated using the free hormone hypothesis. Results: From 604 athletes, 21.5% (n=130) demonstrated severe 25(OH)D deficiency, 37.1% (n=224) deficiency, 26% (n=157) insufficiency and 15.4% (n=93) sufficiency. Serum 25(OH)D concentrations were not associated with BMD at any site. After adjusting for age and race, bioavailable vitamin D was associated with BMD (spine, neck and hip). Mean serum vitamin D binding protein concentrations were not associated with 25(OH)D concentrations (p=0.392). Conclusion: Regardless of age or race, bioavailable vitamin D and not serum 25(OH)D was associated with BMD in a racially diverse athletic population. If vitamin D screening is warranted, clinicians should use appropriate assays to calculate vitamin D binding protein and bioavailable vitamin D levels concentrations than serum 25(OH)D. In turn, prophylactic vitamin D supplementation to â 'correct' insufficient athletes should not be based on serum 25(OH)D measures.
KW - Athlete
KW - Biochemistry
KW - Bone Mineral Density
KW - Bone Density
KW - Humans
KW - Biological Availability
KW - Male
KW - Athletes
KW - Absorptiometry, Photon
KW - Young Adult
KW - Adolescent
KW - Adult
KW - Biomarkers/blood
KW - Vitamin D-Binding Protein/blood
KW - Vitamin D/blood
KW - Parathyroid Hormone/blood
UR - http://www.scopus.com/inward/record.url?scp=85041332830&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/dont-serum-vitamin-d-concentrations-associate-bmd-dxa-case-%C3%A2-bound-wrong-assay-implications-vitamin
U2 - 10.1136/bjsports-2016-097130
DO - 10.1136/bjsports-2016-097130
M3 - Article
C2 - 28798036
AN - SCOPUS:85041332830
SN - 0306-3674
VL - 52
SP - 522
EP - 526
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
IS - 8
ER -