Isolation and characterisation of proteins from Streptococcus pneumoniae for determination of vaccine potential

Abstract

The purpose of this study was to investigate novel pneumococcal proteins for potential
to induce an immune response that cleared an acute pulmonary infection in a mouse
model. Proteins were purified from the cell wall of S. pneumoniae and screened in an
animal model of acute lung infection following mucosa! immunisations. Three proteins
were identified as showing potential as new vaccine candidates and investigations
associated with these proteins are presented in this thesis.

Date of Award	2004
Original language	English
Supervisor	Jennelle Kyd (Supervisor) & Allan W. Cripps (Supervisor)